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提取物通过减轻糖尿病前期大鼠的氧化应激和细胞凋亡，预防高脂饮食和链脲佐菌素诱导的急性肾损伤。

extract prevents acute kidney injury induced by high-fat diet and streptozotocin via alleviation of oxidative stress and apoptosis in pre-diabetic rats.

作者信息

Laorodphun Pongrapee, Chaisen Sutheera, Amattat Sarocha, Maphet Pornchita, Printrakul Narin, Pandith Hataichanok, Panya Aussara, Kongmali Burit, Swe Myat Theingi, Arjinajarn Phatchawan

机构信息

Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.

Interdisciplinary Program in Biotechnology, Faculty of Graduate School, Chiang Mai University, Chiang Mai, Thailand.

出版信息

Front Pharmacol. 2024 Oct 22;15:1464463. doi: 10.3389/fphar.2024.1464463. eCollection 2024.

DOI:10.3389/fphar.2024.1464463
PMID:39502526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11534586/
Abstract

CONTEXT

Obesity and pre-diabetes are associated with renal dysfunction via elevated oxidative stress. Peat moss, or Müll. Hal., Sphagnaceae (SC), are rich in phenolic compounds that enhance antioxidant activity.

OBJECTIVE

SC might show beneficial effects in pre-diabetes-associated renal dysfunction.

MATERIALS AND METHODS

Male Wistar rats, after 4 weeks on a high-fat diet, received low-dose streptozotocin to induce pre-diabetes. Then, the pre-diabetic rats were randomly divided into 4 groups: untreated pre-diabetic rats (P-DM), pre-diabetic rats treated with SC 50 or 100 mg/kg/day (P-DM50 or P-DM100), and pre-diabetic rats treated with metformin 100 mg/kg/day (MET). The drugs were fed by gavage for 4 weeks.

RESULTS

Treatment with SC100 dramatically lowered serum creatinine (S.Cr.), blood urea nitrogen (BUN), and augmented creatinine clearance in pre-diabetic rats. Additionally, SC100 significantly decreased the malondialdehyde level. Furthermore, pre-diabetic rats treated with SC100 significantly upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream mediators, with downregulated apoptotic markers.

DISCUSSION AND CONCLUSION

Our findings provide a scientific basis for the clinical application of SC and a new strategy for the prevention of nephrotoxicity and other kidney disease in the future.

摘要

背景

肥胖和糖尿病前期通过氧化应激升高与肾功能障碍相关。泥炭藓，即泥炭藓科（SC），富含增强抗氧化活性的酚类化合物。

目的

SC可能对糖尿病前期相关的肾功能障碍具有有益作用。

材料与方法

雄性Wistar大鼠在高脂饮食4周后，接受低剂量链脲佐菌素诱导糖尿病前期。然后，将糖尿病前期大鼠随机分为4组：未治疗的糖尿病前期大鼠（P-DM）、接受50或100mg/kg/天SC治疗的糖尿病前期大鼠（P-DM50或P-DM100）以及接受100mg/kg/天二甲双胍治疗的糖尿病前期大鼠（MET）。通过灌胃给药4周。

结果

SC100治疗显著降低了糖尿病前期大鼠的血清肌酐（S.Cr.）、血尿素氮（BUN），并提高了肌酐清除率。此外，SC100显著降低了丙二醛水平。此外，接受SC100治疗的糖尿病前期大鼠显著上调了核因子红细胞2相关因子2（Nrf2）及其下游介质的表达，同时下调了凋亡标志物。

讨论与结论

我们的研究结果为SC的临床应用提供了科学依据，并为未来预防肾毒性和其他肾脏疾病提供了新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/25d7da00e63e/fphar-15-1464463-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/d82d50d17ddf/fphar-15-1464463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/16c1e7889f2e/fphar-15-1464463-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/9713d1135dad/fphar-15-1464463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/8f99ee7ad9c6/fphar-15-1464463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/942d8c7c3257/fphar-15-1464463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/25d7da00e63e/fphar-15-1464463-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/d82d50d17ddf/fphar-15-1464463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/16c1e7889f2e/fphar-15-1464463-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/9713d1135dad/fphar-15-1464463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/8f99ee7ad9c6/fphar-15-1464463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/942d8c7c3257/fphar-15-1464463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da6/11534586/25d7da00e63e/fphar-15-1464463-g006.jpg

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