Bai Bufan, Ma Yingrui, Liu Deng, Zhang Yifei, Zhang Weihong, Shi Rong, Zhou Qianmei
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Intensive Care Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2024 Oct 22;15:1483160. doi: 10.3389/fphar.2024.1483160. eCollection 2024.
DNA damage induced by chemotherapy has duality. It affects the efficacy of chemotherapy and constrains its application. An increasing number of studies have shown that traditional Chinese medicine (TCM) is highly effective in reducing side-effects induced by chemotherapy due to its natural, non-toxic and many sourced from food. Recent advancements have demonstrated survival rates are improved attributable to effective chemotherapy. DNA damage is the principal mechanism underlying chemotherapy. However, not all instances of DNA damage are beneficial. Chemotherapy induces DNA damage in normal cells, leading to side effects. It affects the efficacy of chemotherapy and constrains its application.
This review aims to summarize the dual nature of DNA damage induced by chemotherapy and explore how TCM can mitigate chemotherapy-induced side effects.
The review summarized the latest research progress in DNA damage caused by chemotherapy and the effect of alleviating side effects by TCM. It focused on advantages and disadvantages of chemotherapy, the mechanism of drugs and providing insights for rational and effective clinical treatment and serving as a basis for experiment. In this review, we described the mechanisms of DNA damage, associated chemotherapeutics, and their toxicity. Furthermore, we explored Chinese herb that can alleviate chemotherapy-induced side-effects.
We highlight key mechanisms of DNA damage caused by chemotherapeutics and discuss specific TCM herbs that have shown potential in reducing these side effects. It can provide reference for clinical and basic research.
化疗诱导的DNA损伤具有双重性。它影响化疗疗效并限制其应用。越来越多的研究表明，中药因其天然、无毒且多源于食物，在减轻化疗所致副作用方面具有高效性。近期进展表明，有效的化疗可提高生存率。DNA损伤是化疗的主要作用机制。然而，并非所有DNA损伤都是有益的。化疗会诱导正常细胞发生DNA损伤，从而导致副作用。它影响化疗疗效并限制其应用。
本综述旨在总结化疗诱导的DNA损伤的双重性质，并探讨中药如何减轻化疗所致副作用。
该综述总结了化疗引起的DNA损伤的最新研究进展以及中药减轻副作用的作用。它聚焦于化疗的优缺点、药物作用机制，为合理有效的临床治疗提供见解并作为实验依据。在本综述中，我们描述了DNA损伤的机制、相关化疗药物及其毒性。此外，我们还探索了可减轻化疗所致副作用的中药。
我们强调了化疗药物引起DNA损伤的关键机制，并讨论了在减轻这些副作用方面显示出潜力的特定中药。它可为临床和基础研究提供参考。
