生命不同阶段多次应激事件对代谢综合征发病的影响。

Effects of multiple stress events at different stages of life on the incidence of metabolic syndrome.

机构信息

Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Mental Health Center, Hebei Medical University, Shijiazhuang, China.

出版信息

Front Endocrinol (Lausanne). 2024 Oct 22;15:1419443. doi: 10.3389/fendo.2024.1419443. eCollection 2024.

DOI:10.3389/fendo.2024.1419443

PMID:39502566

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11534591/

Abstract

OBJECTIVE

To investigate the effects of multiple stress events in different stages of life on the incidence of metabolic syndrome (MetS).

METHODS

Miners from Tangshan, China, were recruited for this study. Workers of the Kailuan Mining Group were evaluated to investigate whether exposure to Tangshan earthquakes during the fetal period in 1976. Adult life events and childhood trauma were assessed separately via the Life Event Scale and Childhood Trauma Questionnaire. The subjects were physically examined and general demographic data such as waist circumference were collected. Blood samples were collected for measurement of metabolic parameters. Corticotropin releasing hormone(CRH) levels was measured by enzyme-linked immunosorbent assay (ELISA). The subjects were divided into four groups according to their exposure to traumatic events in different stages of life: no exposure group, 1-exposure group, 2-exposures group, and 3-exposures group. The incidence of MetS, metabolic parameters and CRH levels in each of the four groups was compared.

RESULTS

In all, 626 people were enrolled; of these, 183, 262, 150, and 31 were in the no exposure, 1-exposure, 2-exposures, and 3-exposure groups, respectively. A remarkable variation in the incidence of MetS was observed among the four groups ( 16.462, <0.001). MetS incidence increased with the increasing number of traumatic events, except for in the no exposure group (17.9% in 1-exposure group, 24.7% in 2-exposure group, and 48.4% in the 3-exposure group). Multivariate logistic regression analysis showed that exposure to multiple stress during the fetal, childhood, and adult stages of life represent independent risk factors for developing MetS (=3.134, =1.042-9.429). Smoking increased the risk of developing MetS (=1.809, =1.140-2.871).

CONCLUSIONS

Exposure to multiple traumatic events in distinct life stages increases the risk of developing MetS. Smoking is a risk factor for developing MetS.

摘要

目的

探讨人生不同阶段多重应激事件对代谢综合征（MetS）发生的影响。

方法

本研究招募了来自中国唐山的矿工。通过对开滦矿业集团的工作人员进行评估，调查他们在 1976 年胎儿期是否接触过唐山地震。分别通过生活事件量表和儿童创伤问卷评估成年期生活事件和儿童期创伤。对受试者进行体格检查，并采集腰围等一般人口统计学数据。采集血样测量代谢参数。采用酶联免疫吸附试验（ELISA）测定促肾上腺皮质激素释放激素（CRH）水平。根据受试者在不同生命阶段暴露于创伤性事件的情况将其分为四组：无暴露组、1 次暴露组、2 次暴露组和 3 次暴露组。比较四组代谢综合征的发生率、代谢参数和 CRH 水平。

结果

共纳入 626 人，其中无暴露组、1 次暴露组、2 次暴露组和 3 次暴露组分别为 183、262、150 和 31 人。四组间代谢综合征的发生率存在显著差异（16.462，<0.001）。除无暴露组外，随着创伤性事件次数的增加，代谢综合征的发生率逐渐升高（1 次暴露组为 17.9%，2 次暴露组为 24.7%，3 次暴露组为 48.4%）。多因素 logistic 回归分析显示，胎儿期、儿童期和成年期暴露于多重应激是发生代谢综合征的独立危险因素（=3.134，=1.042-9.429）。吸烟增加了发生代谢综合征的风险（=1.809，=1.140-2.871）。