Department of Diabetes, Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Front Endocrinol (Lausanne). 2024 Oct 22;15:1437711. doi: 10.3389/fendo.2024.1437711. eCollection 2024.
It remains unclear whether the triglyceride-glucose (TyG) index has correlations with gallstones. This study aimed to investigate the association between TyG index and gallstones.
Data was obtained from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). Participants who provided complete data about TyG index and gallstones were included in the analysis. Multivariable regression analysis and subgroup analysis were preformed to estimate the relationship between TyG index and gallstones. Restricted cubic splines (RSC) was employed to calculate the cut off value.
The TyG index was independently associated with gallstones and demonstrates a clear positive correlation (OR = 1.10; 95% CI: 1.01-1.21; p = 0.033). The threshold value is 8.98, showing a positive correlation between TyG index and gallstones when the TyG index is less than 8.98 (Log likelihood ratio P < 0.001). Subgroup analysis indicates that the correlation between TyG and gallstones is mainly observed in individuals with obesity, females, younger individuals, and those with normal blood sugar levels, with these subgroups all acting as mediators between TyG and gallstones.
Higher TyG index was linked to a higher chance of developing gallstones. Managing insulin resistance (IR) could help reduce the risk of gallstones since the TyG index is an indicator of IR.
目前尚不清楚甘油三酯-葡萄糖（TyG）指数与胆结石之间是否存在相关性。本研究旨在探讨 TyG 指数与胆结石之间的关系。
本研究数据来自 2017-2020 年全国健康与营养调查（NHANES）。分析纳入了提供 TyG 指数和胆结石完整数据的参与者。采用多变量回归分析和亚组分析来评估 TyG 指数与胆结石之间的关系。采用受限立方样条（RCS）计算截断值。
TyG 指数与胆结石独立相关，呈明显正相关（OR=1.10；95%CI：1.01-1.21；p=0.033）。阈值为 8.98，当 TyG 指数低于 8.98 时，TyG 指数与胆结石之间呈正相关（对数似然比 P<0.001）。亚组分析表明，TyG 与胆结石之间的相关性主要见于肥胖、女性、年轻个体和血糖正常的个体，这些亚组均作为 TyG 与胆结石之间的中介。
较高的 TyG 指数与更高的胆结石发病几率相关。由于 TyG 指数是胰岛素抵抗（IR）的指标，因此，控制 IR 可能有助于降低胆结石的风险。
