Department of Hepatobiliary Surgery, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, China.
Front Endocrinol (Lausanne). 2024 Jul 11;15:1420999. doi: 10.3389/fendo.2024.1420999. eCollection 2024.
Globally, gallstones represented a prevalent condition of the digestive system, heavily affected by metabolic dysfunctions such as obesity, dyslipidemia, insulin resistance, and diabetes. The triglyceride-glucose (TyG) index served as an accessible novel indicator for evaluating insulin resistance, offering a precise reflection of metabolic conditions. However, no studies have yet explored their relationship. The link between the TyG and gallstone risk was the primary purpose of this study.
Utilized data from the public database, the National Health and Nutrition Examination Survey, for the years 2017-2020. The logit model was utilized to elucidate the connection between the TyG and the gallstones risk. The restricted cubic spline (RCS) analysis served to verify any non-linear relationships existing between them. Sensitivity analyses, encompassing both stratified and interaction analyses, were conducted to identify populations of particular interest and assess potential interactions between covariates and the TyG index.
A total of 4544 individuals were included. The risk of gallstones in high group was 1.6 times that of the low group. The potential cut-off value for the TyG index was 6.19. Above this threshold, there was a 40% heightened risk of gallstones with each one-unit increment in the TyG. The RCS analysis revealed the absence of a non-linear association between them. The populations warranting particular focus included those over 60 years, non-White people, individuals with a body mass index ≥25, smokers, drinkers, those with hypertension, and diabetes. Apart from smoking history, alcohol consumption, and history of diabetes, there were no interactions between other variables and the TyG index.
The current study represented the inaugural investigation into the link between TyG index and the risk of gallstones. A positive correlation existed between them, signifying that an increase in TyG paralleled an elevated risk of gallstones. No non-linear relationship has been found between them. Besides, a 40% increase in gallstone risk accompanied each unit rise in TyG. Considering the convenience and accessibility of TyG in clinical settings, it has a promising potential for clinical application.
全球范围内，胆石症是一种常见的消化系统疾病，受肥胖、血脂异常、胰岛素抵抗和糖尿病等代谢功能障碍的影响较大。三酰甘油-葡萄糖（TyG）指数是评估胰岛素抵抗的一种新的、易于获得的指标，可以准确反映代谢情况。但目前尚无研究探讨其相关性。本研究旨在探讨 TyG 与胆囊结石风险之间的关系。
利用 2017-2020 年美国国家健康和营养调查公共数据库的数据，采用 logit 模型阐明 TyG 与胆囊结石风险之间的关系。采用限制性立方样条（RCS）分析验证二者之间是否存在非线性关系。进行敏感性分析，包括分层和交互分析，以确定特定人群并评估协变量与 TyG 指数之间的潜在相互作用。
共纳入 4544 人。TyG 高分组胆囊结石风险是低分组的 1.6 倍。TyG 指数的潜在截断值为 6.19。TyG 每增加 1 单位，胆囊结石的风险增加 40%。RCS 分析显示二者之间不存在非线性关系。需要特别关注的人群包括 60 岁以上人群、非白种人、BMI≥25 的人群、吸烟者、饮酒者、高血压患者和糖尿病患者。除吸烟史、饮酒史和糖尿病史外，其他变量与 TyG 指数之间无交互作用。
本研究首次探讨了 TyG 指数与胆囊结石风险之间的关系。二者呈正相关，表明 TyG 升高与胆囊结石风险增加相关。二者之间未发现非线性关系。TyG 每增加 1 个单位，胆囊结石的风险增加 40%。鉴于 TyG 在临床实践中的便利性和可获得性，其具有潜在的临床应用前景。
