Lipsitz L A, Fullerton K J
J Am Geriatr Soc. 1986 Apr;34(4):267-70. doi: 10.1111/j.1532-5415.1986.tb04222.x.
Previous studies have identified postprandial systolic blood pressure reductions in old, frail institutionalized subjects, which do not occur in healthy, young subjects, after a morning meal. To evaluate the relative contributions of state of health and time of day to this potentially dangerous abnormality in cardiovascular homeostasis, we measured sitting systolic blood pressure and heart rate before and at intervals after a noon meal, and in identical fashion without a meal, in 21 healthy, community-dwelling elderly subjects (73 +/- 6 years of age) attending a nutrition program. Systolic blood pressure changed a maximum of -11 +/- 9 (SD) mmHg (P = .006, analysis of variance) by 60 minutes after the meal, in contrast to 1 +/- 7 mmHg (NS) by 60 minutes, when no meal was given (P less than .0001, meal versus control studies). There was a highly significant inverse correlation between postprandial and basal sitting systolic blood pressure changes (R = -0.60, P = .004). Healthy community-dwelling elderly demonstrate postprandial reductions in systolic blood pressure which correlate with basal sitting systolic blood pressure. This is consistent with age- and hypertension-related impairment in baroreflex compensation for the hypotensive stress of eating.
先前的研究已发现，在养老院中生活的年老体弱的受试者，在进早餐后会出现餐后收缩压降低的情况，而健康的年轻受试者不会出现这种情况。为了评估健康状况和一天中的时间对这种心血管稳态潜在危险异常的相对影响，我们对参加营养项目的21名健康的社区老年受试者（73±6岁），在午餐前及午餐后每隔一段时间测量其坐位收缩压和心率，并以相同方式在未进餐时进行测量。餐后60分钟时，收缩压最大下降-11±9（标准差）mmHg（方差分析，P = 0.006），而未进餐时60分钟收缩压变化为1±7 mmHg（无显著差异）（进餐与对照研究相比，P＜0.0001）。餐后坐位收缩压变化与基础坐位收缩压变化之间存在高度显著的负相关（R = -0.60，P = 0.004）。健康的社区老年受试者餐后收缩压降低，且与基础坐位收缩压相关。这与年龄和高血压相关的压力反射对进食引起的低血压应激的代偿功能受损是一致的。
