Department of Basic Sciences, Institute of Fisheries Post Graduate Studies, OMR Campus, Tamil Nadu Dr. J. Jayalalithaa Fisheries University, Chennai, Tamil Nadu, India.
J Biochem Mol Toxicol. 2024 Nov;38(11):e70052. doi: 10.1002/jbt.70052.
This comprehensive review discusses the crucial role of copper in human health and disease as an essential trace mineral. It emphasizes the significance of copper while addressing potential risks from imbalances in copper levels, be it excessive or inadequate. The review outlines various challenges in copper research, including toxicity concerns, data limitations, metabolic complexities, genetic influences, nutrient interactions, and resource constraints. Despite these challenges, the review identifies specific research areas needing exploration, such as copper homeostasis regulation, transport mechanisms, gut microbiome interactions, immune function, neurodegenerative diseases, cardiovascular health, cancer, fertility, and reproductive health. The purpose of this review is to explore the important role of copper in human health and disease, which highlights the delicate balance required to avoid deficiency or toxicity. For the researchers and scientists, it provides the gaps in the research, so it aims to provide insights that could advance diagnostic and therapeutic strategies across various medical disciplines.
这篇全面的综述探讨了铜作为一种必需微量元素在人类健康和疾病中的关键作用。它强调了铜的重要性，同时也讨论了铜水平失衡（无论是过多还是不足）带来的潜在风险。该综述概述了铜研究中的各种挑战，包括毒性问题、数据限制、代谢复杂性、遗传影响、营养相互作用和资源限制。尽管存在这些挑战，但该综述确定了需要探索的特定研究领域，如铜动态平衡的调节、运输机制、肠道微生物组的相互作用、免疫功能、神经退行性疾病、心血管健康、癌症、生育和生殖健康。本综述的目的是探讨铜在人类健康和疾病中的重要作用，强调了为避免缺乏或毒性而需要保持的微妙平衡。对于研究人员和科学家来说，这为研究中的空白提供了参考，旨在提供可以推进各个医学领域诊断和治疗策略的见解。
