The Minimally Invasive 1-Hour Esophageal String Test Monitors Therapeutic Changes in Mucosal Inflammation in Eosinophilic Esophagitis.
作者信息
Ackerman Steven J, Kagalwalla Amir F, Pan Zhaoxing, Wechsler Joshua, Keeley Kaitlin, Gonsalves Nirmala, Hirano Ikuo, Zalewski Angelika, Menard-Katcher Paul, Menard-Katcher Calies, Gupta Sandeep K, Chauhan Nikhil, Grozdanovic Milica, Atkins Dan, Nguyen Nathalie, Furuta Glenn T
机构信息
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
出版信息
Am J Gastroenterol. 2025 Jan 1;120(1):254-258. doi: 10.14309/ajg.0000000000003192. Epub 2024 Nov 6.
INTRODUCTION
Endoscopy, standard-of-care for monitoring eosinophilic esophagitis (EoE), assesses mucosal inflammation. The Esophageal String Test (EST), a minimally invasive swallowed capsule and immunoassays, quantifies EoE inflammation. We determined whether the EST/EoEScore can monitor disease in patients undergoing treatment.
METHODS
Thirty-three samples from 14 patients with EoE (7 children, 7 adults) who underwent repeat endoscopies and ESTs were studied. Biopsies were analyzed for peak eosinophil counts; ESTs were analyzed for EoEScores.
RESULTS
Eosinophil counts and EoEScores significantly correlated during treatment, distinguishing patients with active EoE from treatment-associated remissions for 93.9% of ESTs performed.
DISCUSSION
The EST can be used to longitudinally monitor responses to treatment in EoE.
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