• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology.

作者信息

Shimizu Mikito, Okuno Tatsusada

机构信息

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan (Shimizu M, Okuno T).

Department of Neurology, Osaka General Medical Center, Osaka, Japan (Shimizu M).

出版信息

Neural Regen Res. 2025 Sep 1;20(9):2589-2590. doi: 10.4103/NRR.NRR-D-24-00661. Epub 2024 Sep 24.

DOI:10.4103/NRR.NRR-D-24-00661
PMID:39503426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11801283/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f3a/11801283/5f139c0c0c46/NRR-20-2589-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f3a/11801283/399b42415838/NRR-20-2589-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f3a/11801283/5f139c0c0c46/NRR-20-2589-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f3a/11801283/399b42415838/NRR-20-2589-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f3a/11801283/5f139c0c0c46/NRR-20-2589-g002.jpg

相似文献

1
Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology.神经元肌动蛋白屏障的破坏促进了与疾病相关蛋白的进入，从而加剧肌萎缩侧索硬化症的病理过程。
Neural Regen Res. 2025 Sep 1;20(9):2589-2590. doi: 10.4103/NRR.NRR-D-24-00661. Epub 2024 Sep 24.
2
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.携带人类突变超氧化物歧化酶转基因的转基因小鼠会出现类似于人类肌萎缩侧索硬化症病变的神经元细胞骨架病理变化。
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3155-60. doi: 10.1073/pnas.93.7.3155.
3
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.RGMa 破坏神经元肌动蛋白屏障以对抗与疾病相关的蛋白质，并加剧 ALS。
Sci Adv. 2023 Nov 24;9(47):eadg3193. doi: 10.1126/sciadv.adg3193. Epub 2023 Nov 22.
4
Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis.静息态 EEG 揭示肌萎缩侧索硬化症的四个亚表型。
Brain. 2022 Apr 18;145(2):621-631. doi: 10.1093/brain/awab322.
5
Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72.伴有 C9ORF72 基因扩增的肌萎缩侧索硬化症的临床病理特征。
Brain. 2012 Mar;135(Pt 3):751-64. doi: 10.1093/brain/awr365.
6
Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration.运动神经元 TDP-43 蛋白病在进行性核上性麻痹和皮质基底节变性中的作用。
Brain. 2022 Aug 27;145(8):2769-2784. doi: 10.1093/brain/awac091.
7
TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis.肌萎缩侧索硬化症患者基底前脑和下丘脑的 TDP-43 病理学。
Acta Neuropathol Commun. 2014 Dec 24;2:171. doi: 10.1186/s40478-014-0171-1.
8
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.神经元型一氧化氮合酶未参与家族性肌萎缩侧索硬化转基因小鼠模型的发病机制。
Neuroscience. 1999;90(4):1483-92. doi: 10.1016/s0306-4522(98)00492-8.
9
Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis.额颞叶痴呆和肌萎缩侧索硬化的生物标志物发现与开发
Brain. 2022 Jun 3;145(5):1598-1609. doi: 10.1093/brain/awac077.
10
Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p.9p 染色体上 C9ORF72 突变引起的家族性额颞叶痴呆的临床和病理特征。
Brain. 2012 Mar;135(Pt 3):709-22. doi: 10.1093/brain/awr354. Epub 2012 Feb 17.

本文引用的文献

1
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.RGMa 破坏神经元肌动蛋白屏障以对抗与疾病相关的蛋白质，并加剧 ALS。
Sci Adv. 2023 Nov 24;9(47):eadg3193. doi: 10.1126/sciadv.adg3193. Epub 2023 Nov 22.
2
Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion.用 Elezanumab 中和 RGMa 可促进兔大脑中动脉闭塞的脑保护和恢复。
Transl Stroke Res. 2024 Aug;15(4):805-817. doi: 10.1007/s12975-023-01164-2. Epub 2023 Jun 16.
3
Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis.
对肌萎缩侧索硬化症复杂遗传学和病理生理学的新见解。
Lancet Neurol. 2022 May;21(5):465-479. doi: 10.1016/S1474-4422(21)00414-2. Epub 2022 Mar 22.
4
Structure of pathological TDP-43 filaments from ALS with FTLD.ALS 伴 FTLD 患者病理性 TDP-43 纤维的结构。
Nature. 2022 Jan;601(7891):139-143. doi: 10.1038/s41586-021-04199-3. Epub 2021 Dec 8.
5
Protein transmission in neurodegenerative disease.蛋白质在神经退行性疾病中的传递。
Nat Rev Neurol. 2020 Apr;16(4):199-212. doi: 10.1038/s41582-020-0333-7. Epub 2020 Mar 23.
6
A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis.一种人源化抗体靶向错误折叠的 SOD1，改善肌萎缩侧索硬化症小鼠模型的运动症状。
Sci Transl Med. 2018 Dec 5;10(470). doi: 10.1126/scitranslmed.aah3924.
7
Prion-like protein aggregates exploit the RHO GTPase to cofilin-1 signaling pathway to enter cells.朊病毒样蛋白聚集物利用 RHO GTPase 共肌动蛋白-1 信号通路进入细胞。
EMBO J. 2018 Mar 15;37(6). doi: 10.15252/embj.201797822. Epub 2018 Mar 1.
8
Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury.针对排斥性导向分子-a 的中和抗体治疗促进了灵长类脊髓损伤模型中受损手动灵巧性的恢复。
Cereb Cortex. 2019 Feb 1;29(2):561-572. doi: 10.1093/cercor/bhx338.
9
Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.突变型原肌球蛋白1转基因小鼠重现了运动神经元疾病的主要特征。
Hum Mol Genet. 2017 Feb 15;26(4):686-701. doi: 10.1093/hmg/ddw429.
10
RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.RGMs：结构见解、分子调控及下游信号传导
Trends Cell Biol. 2017 May;27(5):365-378. doi: 10.1016/j.tcb.2016.11.009. Epub 2016 Dec 19.