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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems.

作者信息

Salasova Alena, Nykjær Anders

机构信息

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Centre of Excellence PROMEMO, Department of Biomedicine, Aarhus University, Aarhus, Denmark.

出版信息

Neural Regen Res. 2025 Sep 1;20(9):2591-2593. doi: 10.4103/NRR.NRR-D-24-00734. Epub 2024 Sep 6.

DOI:10.4103/NRR.NRR-D-24-00734
PMID:39503427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11801297/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de0/11801297/e8a1d3d4f760/NRR-20-2591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de0/11801297/e8a1d3d4f760/NRR-20-2591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de0/11801297/e8a1d3d4f760/NRR-20-2591-g001.jpg

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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems.颗粒前体蛋白依赖性SorCS2信号通路在健康和患病神经系统中的新兴潜力。
Neural Regen Res. 2025 Sep 1;20(9):2591-2593. doi: 10.4103/NRR.NRR-D-24-00734. Epub 2024 Sep 6.
2
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Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment.在神经发育过程中，功能相关的vps10p受体sortilin和SorCS2高度分离定位。
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本文引用的文献

1
SorCS2 binds progranulin to regulate motor neuron development.SorCS2 通过结合颗粒蛋白前体来调节运动神经元的发育。
Cell Rep. 2023 Nov 28;42(11):113333. doi: 10.1016/j.celrep.2023.113333. Epub 2023 Oct 27.
2
Neurodevelopmental Disorders: Past, Present, and Future.神经发育障碍：过去、现在与未来
Children (Basel). 2022 Dec 24;10(1):31. doi: 10.3390/children10010031.
3
Development, wiring and function of dopamine neuron subtypes.多巴胺神经元亚型的发育、连接及功能
Nat Rev Neurosci. 2023 Mar;24(3):134-152. doi: 10.1038/s41583-022-00669-3. Epub 2023 Jan 18.
4
Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer's disease.发现备忘录：VPS10p-结构域受体在阿尔茨海默病中的多功能相互作用。
Mol Neurodegener. 2022 Nov 18;17(1):74. doi: 10.1186/s13024-022-00576-2.
5
Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development.清除思绪：神经发育过程中细胞死亡后碎片清除的机制。
Annu Rev Neurosci. 2022 Jul 8;45:177-198. doi: 10.1146/annurev-neuro-110920-022431. Epub 2022 Feb 28.
6
Progranulin as a therapeutic target in neurodegenerative diseases.颗粒蛋白前体作为神经退行性疾病的治疗靶点。
Trends Pharmacol Sci. 2022 Aug;43(8):641-652. doi: 10.1016/j.tips.2021.11.015. Epub 2022 Jan 15.
7
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.颗粒蛋白前体作为组织蛋白酶D的伴侣蛋白，在体内刺激轴突生长。
Hum Mol Genet. 2017 Aug 1;26(15):2850-2863. doi: 10.1093/hmg/ddx162.
8
SorCS2 is required for BDNF-dependent plasticity in the hippocampus.SorCS2 对于海马体中 BDNF 依赖性的可塑性是必需的。
Mol Psychiatry. 2016 Dec;21(12):1740-1751. doi: 10.1038/mp.2016.108. Epub 2016 Jul 26.
9
SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.SorCS2 调节多巴胺能神经布线，并在外周神经胶质中被加工成凋亡的双链受体。
Neuron. 2014 Jun 4;82(5):1074-87. doi: 10.1016/j.neuron.2014.04.022.
10
Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.Sortilin 介导的内吞作用决定了额颞叶痴呆蛋白颗粒蛋白前体的水平。
Neuron. 2010 Nov 18;68(4):654-67. doi: 10.1016/j.neuron.2010.09.034.