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Are the pharmacokinetic data of meropenem studied in CSF of a mixed population composed of patients with cerebral infections and patients with extracerebral infections really helpful for clinicians treating CNS infections?

作者信息

Gatti Milo, Pea Federico

机构信息

Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Clinical Pharmacology Unit, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

出版信息

Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0145324. doi: 10.1128/aac.01453-24. Epub 2024 Nov 6.

DOI:10.1128/aac.01453-24
PMID:39503484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11619360/
Abstract
摘要

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本文引用的文献

1
Meropenem pharmacokinetics in cerebrospinal fluid: comparing intermittent and continuous infusion strategies in critically ill patients-a prospective cohort study.美罗培南在脑脊液中的药代动力学：比较危重症患者中间断和持续输注策略的前瞻性队列研究。
Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0045124. doi: 10.1128/aac.00451-24. Epub 2024 Jul 31.
2
Impact of attaining aggressive vs. conservative PK/PD target on the clinical efficacy of beta-lactams for the treatment of Gram-negative infections in the critically ill patients: a systematic review and meta-analysis.达到积极与保守 PK/PD 目标对重症患者革兰氏阴性感染治疗中β-内酰胺类药物临床疗效的影响：系统评价和荟萃分析。
Crit Care. 2024 Apr 16;28(1):123. doi: 10.1186/s13054-024-04911-5.
3
Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Meropenem in Neurocritical Care Patients: a Prospective Two-Center Study.神经危重症患者美罗培南的血浆和脑脊液群体药代动力学：一项前瞻性的双中心研究。
Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0014222. doi: 10.1128/aac.00142-22. Epub 2022 Jul 6.
4
A dosing nomograph for cerebrospinal fluid penetration of meropenem applied by continuous infusion in patients with nosocomial ventriculitis.应用于医院获得性脑室炎患者的美罗培南连续输注时的脑脊液渗透剂量图示。
Clin Microbiol Infect. 2022 Jul;28(7):1022.e9-1022.e16. doi: 10.1016/j.cmi.2022.02.017. Epub 2022 Feb 17.
5
Cerebrospinal Fluid Concentrations of Meropenem and Vancomycin in Ventriculitis Patients Obtained by TDM-Guided Continuous Infusion.通过治疗药物监测（TDM）引导的持续输注获得的脑室炎患者脑脊液中美罗培南和万古霉素的浓度
Antibiotics (Basel). 2021 Nov 20;10(11):1421. doi: 10.3390/antibiotics10111421.
6
Pharmacokinetic/pharmacodynamic analysis of meropenem, by Monte Carlo simulation, in both plasma and cerebrospinal fluid in patients with cerebral hemorrhage after external ventricular drainage
.通过蒙特卡洛模拟对美罗培南在脑室引流术后脑出血患者血浆和脑脊液中的药代动力学/药效学分析。
Int J Clin Pharmacol Ther. 2020 Jan;58(1):50-56. doi: 10.5414/CP203606.
7
Pharmacokinetics of meropenem in plasma and cerebrospinal fluid in patients with intraventricular hemorrhage after lateral ventricle drainage.美罗培南在侧脑室引流术后脑室出血患者血浆和脑脊液中的药代动力学
Eur J Clin Pharmacol. 2019 Apr;75(4):595-597. doi: 10.1007/s00228-018-02606-9. Epub 2018 Dec 15.
8
Intrathecal penetration of meropenem and vancomycin administered by continuous infusion in patients suffering from ventriculitis-a retrospective analysis.鞘内注射美罗培南和万古霉素持续输注治疗脑室炎患者的回顾性分析。
Acta Neurochir (Wien). 2018 Nov;160(11):2099-2105. doi: 10.1007/s00701-018-3680-z. Epub 2018 Sep 21.
9
Evaluation of Meropenem Penetration into Cerebrospinal Fluid in Patients with Meningitis After Neurosurgery.神经外科手术后脑膜炎患者美罗培南脑脊液穿透性评估
World Neurosurg. 2017 Feb;98:525-531. doi: 10.1016/j.wneu.2016.11.040. Epub 2016 Nov 17.
10
Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study.美罗培南在确诊或疑似脑室炎的神经重症患者中的脑脊液穿透性：一项前瞻性观察研究。
Crit Care. 2016 Oct 24;20(1):343. doi: 10.1186/s13054-016-1523-y.