Bao Xiao-mei, He Qing, Wang Ying, Huang Zhi-hui, Yuan Zeng-qiang
Department of Basic Medicine, Wenzhou Medical University, Wenzhou 325035, China.
University of Chinese Academy of Sciences, Beijing 100039, China.
Yi Chuan. 2017 Jul 20;39(7):630-641. doi: 10.16288/j.yczz.17-069.
The Hippo signaling pathway, consisting of a highly conserved kinase cascade and downstream transcription co-activators YAP (Yes-associated protein)/TAZ (transcriptional coactivator with PDZ-binding motif), plays a key role in tissue homeostasis and organ size control by regulating the proliferation, differentiation and apoptosis of cells. During normal development, the precise control of neural cell numbers and spatial distributions of these neural cells is important for brain development. Recent studies have shown that the Hippo/YAP signaling pathway is actively involved in the self-renewal of neural stem cells, proliferation of neural progenitor cells, differentiation and activation of glial cells, and myelination of glial cells as well as in the development of neurological diseases. Due to its prominent role in the nervous system, it is necessary to further study on this pathway. In this review, we summarize the recent studies and focus on the roles and mechanisms of the Hippo/YAP signaling pathway in the nervous system, and provide insights for neural development and neural injury diseases.
河马信号通路由高度保守的激酶级联反应和下游转录共激活因子YAP（Yes相关蛋白）/TAZ（具有PDZ结合基序的转录共激活因子）组成，通过调节细胞的增殖、分化和凋亡，在组织稳态和器官大小控制中发挥关键作用。在正常发育过程中，神经细胞数量的精确控制以及这些神经细胞的空间分布对大脑发育至关重要。最近的研究表明，河马/YAP信号通路积极参与神经干细胞的自我更新、神经祖细胞的增殖、神经胶质细胞的分化和激活以及神经胶质细胞的髓鞘形成，以及神经疾病的发展。由于其在神经系统中的突出作用，有必要对该通路进行进一步研究。在这篇综述中，我们总结了最近的研究，并聚焦于河马/YAP信号通路在神经系统中的作用和机制，为神经发育和神经损伤疾病提供见解。
