Green Lab, Department of Prosthodontics, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai, 600077, Tamil Nadu, India.
Ocean and Fisheries Development International Cooperation Institute, Pukyong National University. Busan 48513, Republic of Korea; International Graduate Program of Fisheries Science, Pukyong National University, Busan, 48513, Republic of Korea; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan, 48513, Republic of Korea.
Microb Pathog. 2024 Dec;197:107103. doi: 10.1016/j.micpath.2024.107103. Epub 2024 Nov 5.
Pseudomonas aeruginosa is an opportunistic pathogen designated as a high-priority pathogen because of its role in major healthcare-associated and nosocomial infections. Biofilm production by these bacteria is one of the adaptive resistance mechanisms to traditional antibiotics, making treatment challenging, especially for immunocompromised patients. P. aeruginosa also produces a variety of virulence factors, which aid in invasion, adhesion, persistence, and immune system protection. Recent advances in nanotechnology-based therapy, notably the application of bioinspired metal and metal-oxide nanomaterials, have been seen as a viable way to control P. aeruginosa biofilm and virulence. Because of its ease of growth and culture, synthesizing metal and metal-oxide nanomaterials using bacterial species has become one of the most environmentally benign green synthesis options. The application of bacterial-inspired nanomaterials is particularly successful for targeted control of P. aeruginosa infection due to interactions with cell membrane components and transport systems. This paper delves into and provides a complete overview of the application of bacterial-inspired metal and metal-oxide nanomaterials to treat P. aeruginosa infection by targeting biofilm and virulence characteristics. The review focused on synthesizing and applying gold, silver, copper, iron, magnetite, and zinc oxide nanomaterials to mitigate P. aeruginosa biofilm and virulence. The underlying mechanism of these metal and metal-oxide nanoparticles in relation to biofilm and virulence features has also been thoroughly discussed. The current review introduces novel approaches to treating and controlling drug-resistant P. aeruginosa using bacterial-inspired nanomaterials as a targeted therapeutic strategy.
铜绿假单胞菌是一种机会性病原体，因其在主要的医疗保健相关和医院感染中的作用而被指定为高优先级病原体。这些细菌产生生物膜是对传统抗生素产生适应性耐药的机制之一，这使得治疗变得具有挑战性，特别是对于免疫功能低下的患者。铜绿假单胞菌还产生多种毒力因子，有助于入侵、黏附、持续存在和免疫系统保护。基于纳米技术的治疗方法的最新进展，特别是仿生金属和金属氧化物纳米材料的应用，被视为控制铜绿假单胞菌生物膜和毒力的可行方法。由于其易于生长和培养，使用细菌合成金属和金属氧化物纳米材料已成为最环保的绿色合成选择之一。由于与细胞膜成分和运输系统的相互作用，细菌启发的纳米材料在针对铜绿假单胞菌感染的靶向控制方面的应用特别成功。本文深入探讨并全面概述了仿生金属和金属氧化物纳米材料在针对生物膜和毒力特征治疗铜绿假单胞菌感染中的应用。综述重点介绍了金、银、铜、铁、磁铁矿和氧化锌纳米材料的合成和应用，以减轻铜绿假单胞菌生物膜和毒力。还彻底讨论了这些金属和金属氧化物纳米颗粒与生物膜和毒力特征相关的潜在机制。本综述介绍了使用细菌启发的纳米材料作为靶向治疗策略治疗和控制耐药物铜绿假单胞菌的新方法。
