Department of Urology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea.
Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Investig Clin Urol. 2024 Nov;65(6):587-592. doi: 10.4111/icu.20240280.
This study aimed to analyze the sleep patterns of patients with nocturnal enuresis (NE) using a wearable brain-wave-sensing device.
We prospectively analyzed 10 of the 14 patients who visited the hospital for NE between August 2023 and July 2024 and agreed to participate in the study. Four patients were excluded owing to pairing errors and loss to follow-up. Participants were instructed to maintain a frequency volume chart for 1 week and sleep while wearing MUSE-S™, a wearable brain-wave detection device. We monitored the arousal threshold state based on sleep patterns when NE occurred in all patients.
The median age of the patients was 8.7 years (interquartile range, 7.0-10.6), and 4 patients (40.0%) were male. In all participants, non-rapid eye movement (NREM) deep sleep was the dominant stage in the early part of sleep, whereas NREM light sleep was dominant in the middle part. The arousal threshold was high in the early part of sleep and decreased toward the end. A poor response to enuretic alarms was observed when NE occurred during the NREM deep-dominant period. In contrast, a good response was observed when NE occurred during the NREM light-dominant period.
Differences in sleep stages influence the arousal threshold more than individual characteristics. To effectively manage the NE, focusing on the timing of urination is important in the latter part of the sleep period.
本研究旨在使用可穿戴脑波感应设备分析遗尿症（NE）患者的睡眠模式。
我们前瞻性分析了 2023 年 8 月至 2024 年 7 月间因 NE 就诊并同意参与研究的 14 名患者中的 10 名。由于配对错误和随访丢失，有 4 名患者被排除在外。参与者被指示在佩戴 MUSE-S™，一种可穿戴脑波检测设备的情况下，保持 1 周的频率体积图表并进行睡眠。我们监测了所有患者遗尿时的觉醒阈值状态，基于睡眠模式。
患者的中位年龄为 8.7 岁（四分位距，7.0-10.6），4 名患者（40.0%）为男性。在所有参与者中，非快速眼动（NREM）深度睡眠是睡眠早期的主导阶段，而 NREM 轻度睡眠在睡眠中期占主导地位。觉醒阈值在睡眠早期较高，并在接近尾声时降低。当遗尿发生在 NREM 深度主导期时，遗尿警报的反应较差。相比之下，当遗尿发生在 NREM 轻度主导期时，反应较好。
睡眠阶段的差异比个体特征更能影响觉醒阈值。为了有效管理 NE，在睡眠后期关注排尿时间很重要。
