State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China.
Nat Commun. 2024 Nov 6;15(1):9592. doi: 10.1038/s41467-024-53824-y.
The clinical treatments of maxillofacial bone defects pose significant challenges due to complex microenvironments, including severe inflammation, high levels of reactive oxygen species (ROS), and potential bacterial infection. Herein, we propose the de novo design of an efficient, versatile, and precise electron-donable heterojunction with synergetic Ru-Cu pair sites (Ru-Cu/EDHJ) for superior biocatalytic regeneration of inflammatory mandible defects and pH-controlled antibacterial therapies. Our studies demonstrate that the unique structure of Ru-Cu/EDHJ enhances the electron density of Ru atoms and optimizes the binding strength of oxygen species, thus improving enzyme-like catalytic performance. Strikingly, this biocompatible Ru-Cu/EDHJ can efficiently switch between ROS scavenging in neutral media and ROS generation in acidic media, thus simultaneously exhibiting superior repair functions and bioadaptive antibacterial properties in treating mandible defects in male mice. We believe synthesizing such biocatalytic heterojunctions with exceptional enzyme-like capabilities will offer a promising pathway for engineering ROS biocatalytic materials to treat trauma, tumors, or infection-caused maxillofacial bone defects.
由于复杂的微环境，包括严重的炎症、高水平的活性氧 (ROS) 和潜在的细菌感染，颌面骨缺损的临床治疗带来了重大挑战。在此，我们提出了一种高效、多功能和精确的电子供体杂化的从头设计，具有协同的 Ru-Cu 对位点（Ru-Cu/EDHJ），用于卓越的生物催化炎症性下颌骨缺损再生和 pH 控制的抗菌治疗。我们的研究表明，Ru-Cu/EDHJ 的独特结构增强了 Ru 原子的电子密度，并优化了氧物种的结合强度，从而提高了类酶的催化性能。引人注目的是，这种生物相容性的 Ru-Cu/EDHJ 可以在中性介质中高效地清除 ROS，并在酸性介质中产生 ROS，因此在治疗雄性小鼠下颌骨缺损时，同时表现出卓越的修复功能和生物适应性抗菌性能。我们相信，合成具有出色类酶能力的这种生物催化杂化材料将为工程 ROS 生物催化材料提供一条有前途的途径，用于治疗创伤、肿瘤或感染引起的颌面骨缺损。
