Huang Lingyi, Li Tiantian, Geng Wei, Xie Xiaodong, Wang Peiqi, Deng Yuting, Gao Yang, Bai Ding, Tang Tian, Cheng Chong
Department of Endodontics, Department of Orthodontics, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Small. 2025 Feb;21(8):e2407046. doi: 10.1002/smll.202407046. Epub 2024 Oct 29.
Diabetic wound healing is a formidable challenge, often complicated by biofilms, immune dysregulation, and hindered vascularization within the wound environments. The intricate interplay of these microenvironmental factors has been a significant oversight in the evolution of therapeutic strategies. Herein, the design of an efficient and versatile oxygen-bonded amorphous transition metal dichalcogenide biocatalyst (aRuS-O) with pH-responsive reactive oxygen biocatalysis for combined antibacterial and anti-inflammatory therapies in promoting diabetic wound healing is reported. Leveraging the incorporation of Ru─O bonds, aRuS-O exhibits optimized adsorption/desorption behavior of oxygen intermediates, thereby enhancing both the reactive oxygen species (ROS) generation activity in acidic conditions and ROS scavenging performance in neutral environments. Remarkably, aRuS-O demonstrates exceptional bactericidal potency within infected milieus through biocatalytic ROS generation. Beyond its antimicrobial capability, post-eradication, aRuS-O serves a dual role in mitigating oxidative stress in inflammatory wounds, providing robust cellular protection and fostering an M2-phenotype polarization of macrophages, which is pivotal for accelerating the wound repair process. The findings underscore the multifaceted efficacy of aRuS-O, which harmoniously integrates high antibacterial action with anti-inflammatory and pro-angiogenic properties. This triad of functionalities positions aRuS-O as a promising candidate for the comprehensive management of complex diabetic ulcers, addressing the unmet needs in the current therapeutics.
糖尿病伤口愈合是一项艰巨的挑战，常常因生物膜、免疫失调以及伤口环境中血管生成受阻而变得复杂。在治疗策略的发展过程中，这些微环境因素之间复杂的相互作用一直被严重忽视。在此，我们报道了一种高效且通用的氧键合非晶态过渡金属二硫属化物生物催化剂（aRuS-O）的设计，其具有pH响应性活性氧生物催化作用，用于在促进糖尿病伤口愈合方面进行联合抗菌和抗炎治疗。通过引入Ru─O键，aRuS-O展现出优化的氧中间体吸附/解吸行为，从而增强了酸性条件下活性氧（ROS）的生成活性以及中性环境中的ROS清除性能。值得注意的是，aRuS-O通过生物催化ROS生成在受感染环境中表现出卓越的杀菌效力。除了抗菌能力外，在根除细菌后，aRuS-O在减轻炎症伤口中的氧化应激方面发挥双重作用，提供强大的细胞保护并促进巨噬细胞的M2表型极化，这对于加速伤口修复过程至关重要。这些发现强调了aRuS-O的多方面功效，它将高抗菌作用与抗炎和促血管生成特性和谐地整合在一起。这三种功能使aRuS-O成为综合管理复杂糖尿病溃疡的有希望的候选者，满足了当前治疗中未满足的需求。
