Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, China.
Sci Rep. 2024 Nov 6;14(1):26942. doi: 10.1038/s41598-024-76314-z.
With increasing life spans, breast cancer (BC) survivors may face the possibility of developing second primary cancer (SPC), which can considerably shorten survival. Lung cancer (LC) is a common SPC among BC survivors. This study explored the association between these two cancers through Mendelian randomization (MR) analysis. A bidirectional two-sample MR analysis was conducted with BC genome-wide association study (GWAS) data from the Breast Cancer Association Consortium (BCAC) included 228,951 individuals and the GWAS summary statistics from the Transdisciplinary Research in Cancer of the Lung (TRICL) of LC included 112,781 individuals. The IVW method and MR-RAPS method showed a causal effect of overall BC on lung adenocarcinoma (LUAD) (IVW: OR = 1.060, 95% CI = 1.008-1.116, P = 0.024; MR-RAPS: OR = 1.059, 95% CI = 1.005-1.116, P = 0.033), which indicated that patients with BC had an increased risk of LUAD. However, there is no strong evidence for a causal effect of LUAD on BC. Our study revealed a causal effect of BC on second primary LUAD, suggesting that we should intensify screening for second primary LC in BC survivors. Early intervention and treatment for patients with second primary LC are needed to reduce mortality in BC survivors.
随着寿命的延长，乳腺癌（BC）幸存者可能面临发展第二原发癌（SPC）的可能性，这可能会大大缩短生存时间。肺癌（LC）是 BC 幸存者中常见的 SPC。本研究通过孟德尔随机化（MR）分析探讨了这两种癌症之间的关联。使用包含 228951 人的乳腺癌协会联盟（BCAC）的 BC 全基因组关联研究（GWAS）数据和包含 112781 人的 LC 的癌症转化研究（TRICL）的 GWAS 汇总统计数据进行了双向两样本 MR 分析。IVW 方法和 MR-RAPS 方法显示总体 BC 对肺腺癌（LUAD）有因果影响（IVW：OR=1.060，95%CI=1.008-1.116，P=0.024；MR-RAPS：OR=1.059，95%CI=1.005-1.116，P=0.033），这表明 BC 患者发生 LUAD 的风险增加。然而，LUAD 对 BC 没有因果关系的有力证据。我们的研究揭示了 BC 对第二原发 LUAD 的因果影响，表明我们应该加强对 BC 幸存者的第二原发 LC 筛查。需要对第二原发 LC 患者进行早期干预和治疗，以降低 BC 幸存者的死亡率。
