Meier E, Jørgensen O S
J Neurochem. 1986 Apr;46(4):1256-62. doi: 10.1111/j.1471-4159.1986.tb00647.x.
The effect of gamma-aminobutyric acid (GABA) on the expression of the neuron-associated D2 and neuron-specific enolase (NSE) was studied during development in culture of cerebellar granule cells. It was found that the presence of GABA during culture development increased the overall protein content. D2 content was also increased but not above the general increase in protein whereas NSE increased above the general level of protein. The presence of GABA in the growth medium also appeared to accelerate the changes in molecular forms of D2 and NSE seen during neuronal development. This suggests that GABA promotes or accelerates the general maturation of neurons, as these two neuron-associated proteins otherwise differ from each other with respect to their subcellular localization and their physiological and biochemical properties.
在小脑颗粒细胞培养发育过程中，研究了γ-氨基丁酸（GABA）对神经元相关D2和神经元特异性烯醇化酶（NSE）表达的影响。结果发现，在培养发育过程中存在GABA可增加总体蛋白质含量。D2含量也增加了，但未超过蛋白质的总体增加量，而NSE增加量超过了蛋白质的总体水平。生长培养基中存在GABA似乎也加速了神经元发育过程中所见D2和NSE分子形式的变化。这表明GABA促进或加速了神经元的总体成熟，因为这两种神经元相关蛋白在亚细胞定位以及生理和生化特性方面彼此不同。
