Wakayama Y, Shibuya S
J Neurol Sci. 1986 Jan;72(1):31-42. doi: 10.1016/0022-510x(86)90033-x.
Rat extensor digitorum longus (EDL) muscles exposed to bupivacaine for 15 min were studied by freeze-fracture electron microscopy. In the bupivacaine-treated and control muscle plasma membranes we studied (1) caveolar density, (2) orthogonal array density, (3) orthogonal array subunit particle density per one orthogonal array and (4) non-array intramembranous particle density. We found a conspicuous decrease of caveolar density and a statistically significant decrease of non-array particle density. Although the orthogonal array density showed a tendency to decrease, the orthogonal array subunit particle density per one orthogonal array was not affected. We also noted aggregation of intramembranous particles and orthogonal arrays. The findings differed from those seen in Duchenne muscle plasma membrane in some respects.
通过冷冻断裂电子显微镜研究了暴露于布比卡因15分钟的大鼠趾长伸肌（EDL）。在布比卡因处理的和对照肌肉的质膜中，我们研究了（1）小窝密度、（2）正交阵列密度、（3）每个正交阵列的正交阵列亚基颗粒密度以及（4）非阵列膜内颗粒密度。我们发现小窝密度显著降低，非阵列颗粒密度有统计学意义的降低。尽管正交阵列密度有降低的趋势，但每个正交阵列的正交阵列亚基颗粒密度未受影响。我们还注意到膜内颗粒和正交阵列的聚集。这些发现与杜兴肌质膜中的发现在某些方面有所不同。
