Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36 of Sanhao Street, Heping District, Shenyang, 110004, China.
Eur J Med Res. 2024 Nov 6;29(1):536. doi: 10.1186/s40001-024-02132-8.
This study was designed to compare the clinical data of vesicoureteral reflux (VUR) in children with and without an allergic constitution.
The clinical data of patients hospitalized with VUR due to a urinary tract infection (UTI) between September 1, 2019, and December 31, 2020, were retrospectively analyzed. The patients were divided into two groups: an anallergic constitution group (AC group) and a non-allergic constitution (NAC group), and their UTIs and VUR were compared at baseline and during the follow-up period.
(1) Between September 1, 2019, and December 31, 2020, a total of 284 children were hospitalized at Shengjing Hospital Affiliated to China Medical University due to a UTI. These children included 37 cases with primary VUR and 247 cases without VUR (including 59 cases of non-VUR urinary malformation). The proportion of children with an allergic constitution was significantly higher in the patients with VUR than it was in those without VUR or with other urinary malformations (72.97% vs. 48.18% vs. 50.85%, P = 0.005, 0.032). (2) At baseline, the levels of immunoglobulin and immunoglobulin E in the AC group were significantly higher than those in the NAC group (P = 0.042, 0.017). (3) During the follow-up period, the number of recurrent UTI cases in the AC group was significantly higher than that in the NAC group (0.70 ± 0.91 vs. 0.10 ± 0.32, P= 0.005). The difference between the two groups in the VUR remission rate was not statistically significant (40% vs. 50%, P = 0.563). (4) During the follow-up period, the differences in the remission rates of recurrent UTIs and VUR in the two groups were not statistically significant.
The incidence of having an allergic constitution is high in patients with VUR, and patients with an allergic constitution present with a higher frequency of recurrent UTIs.
本研究旨在比较伴有和不伴有过敏体质的儿童的膀胱输尿管反流（VUR）的临床数据。
回顾性分析 2019 年 9 月 1 日至 2020 年 12 月 31 日因尿路感染（UTI）住院的 VUR 患者的临床资料。患者分为两组：无过敏体质组（AC 组）和过敏体质组（NAC 组），比较两组患者在基线时和随访期间的 UTI 和 VUR。
（1）2019 年 9 月 1 日至 2020 年 12 月 31 日，中国医科大学附属盛京医院共收治 284 例因 UTI 住院的患儿，其中原发性 VUR 37 例，无 VUR（包括非 VUR 尿路畸形 59 例）247 例。VUR 患儿的过敏体质比例明显高于无 VUR 或其他尿路畸形患儿（72.97%比 48.18%比 50.85%，P=0.005，0.032）。（2）基线时，AC 组的免疫球蛋白和免疫球蛋白 E 水平明显高于 NAC 组（P=0.042，0.017）。（3）随访期间，AC 组复发性 UTI 例数明显多于 NAC 组（0.70±0.91 比 0.10±0.32，P=0.005）。两组 VUR 缓解率差异无统计学意义（40%比 50%，P=0.563）。（4）随访期间，两组复发性 UTI 和 VUR 的缓解率差异无统计学意义。
VUR 患儿过敏体质发生率高，过敏体质患儿复发性 UTI 发生率高。
