Zheng Yue, Zhang Zhou, Hou Ling, Wang Xiuli, Jiang Kailei, Zhang Shucheng, Du Yue
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Front Pediatr. 2021 May 7;9:646118. doi: 10.3389/fped.2021.646118. eCollection 2021.
The present study aimed to analyze the risk factors correlated with overactive bladder (OAB), observe the effects of desloratadine in the treatment of OAB, and explore the correlation between OAB and atopic constitution in children. Correlation and binary logistic regression analysis of the medical data from 447 children clinically diagnosed with OAB from June 2019 to June 2020 were conducted. The data included a history of urticaria, eczema, itchy skin, and allergic rhinitis or allergic cough. The OABSS scores before and after treatment with desloratadine were compared to evaluate the effectiveness of desloratadine for OAB. The risk factors for OAB in children included eczema, allergic rhinitis or allergic cough, itchy skin, and the levels of total blood IgE. Desloratadine was 96.5% effective in treating cases with risk factors including eczema, allergic rhinitis or allergic cough, and itchy skin. There existed statistical significance in the difference in OABSS scores before and after the treatment of desloratadine ( < 0.05). OAB in children was correlated with atopic manifestations such as eczema, itchy skin, allergic rhinitis, or allergic cough. Desloratadine was safe and effective in the treatment of OAB in children with atopic manifestations.
本研究旨在分析与膀胱过度活动症（OAB）相关的危险因素，观察地氯雷他定治疗OAB的效果，并探讨儿童OAB与特应性体质之间的相关性。对2019年6月至2020年6月临床诊断为OAB的447例儿童的医学数据进行相关性和二元逻辑回归分析。数据包括荨麻疹、湿疹、皮肤瘙痒以及过敏性鼻炎或过敏性咳嗽病史。比较地氯雷他定治疗前后的OABSS评分，以评估地氯雷他定治疗OAB的有效性。儿童OAB的危险因素包括湿疹、过敏性鼻炎或过敏性咳嗽、皮肤瘙痒以及总血IgE水平。地氯雷他定对伴有湿疹、过敏性鼻炎或过敏性咳嗽以及皮肤瘙痒等危险因素的病例治疗有效率为96.5%。地氯雷他定治疗前后OABSS评分差异有统计学意义（<0.05）。儿童OAB与湿疹、皮肤瘙痒、过敏性鼻炎或过敏性咳嗽等特应性表现相关。地氯雷他定治疗有特应性表现的儿童OAB安全有效。
