儿童膀胱过度活动症与过敏之间的临床关联
Clinical Correlation Between Overactive Bladder and Allergy in Children.
作者信息
Yin Lu, Zhang Zhou, Zheng Yue, Hou Ling, Zhao Cheng-Guang, Wang Xiu-Li, Jiang Kai-Lei, Du Yue
机构信息
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
出版信息
Front Pediatr. 2022 Jan 14;9:813161. doi: 10.3389/fped.2021.813161. eCollection 2021.
BACKGROUND
The International Children's Continence Society defines overactive bladder (OAB) as a clinical syndrome characterized by urgency of urination usually accompanied by frequent urination and nocturia symptoms. This study aims to explore the correlation between overactive bladder (OAB) and allergy in children.
METHOD
The clinical characteristics of 918 patients diagnosed with OAB from January 2020 to March 2021 were retrospectively analyzed. Risk factors for OAB were analyzed using logistic regression analysis, and the effect of desloratadine in the treatment of OAB was evaluated.
RESULTS
The incidence of allergic cough or allergic rhinitis in the mild OAB group was higher than the moderate-severe group. Urodynamics demonstrated that the proportion of patients with a sensitive bladder in the overactive detrusor group was significantly higher than the non-overactive detrusor group. The effective rate of treatment of OAB in patients complicated with allergies and taking desloratadine was 90.14%, which was significantly higher than in patients who were not taking desloratadine, and blood IgE level was a risk factor of ineffective treatment with desloratadine.
CONCLUSION
OAB is correlated with allergies in children, and desloratadine can effectively improve OAB symptoms.
背景
国际儿童尿控协会将膀胱过度活动症（OAB）定义为一种临床综合征，其特征为尿急，通常伴有尿频和夜尿症状。本研究旨在探讨儿童膀胱过度活动症（OAB）与过敏之间的相关性。
方法
回顾性分析2020年1月至2021年3月期间诊断为OAB的918例患者的临床特征。采用逻辑回归分析OAB的危险因素，并评估地氯雷他定治疗OAB的效果。
结果
轻度OAB组中过敏性咳嗽或过敏性鼻炎的发生率高于中重度组。尿动力学显示，逼尿肌过度活动组膀胱敏感患者的比例显著高于逼尿肌无过度活动组。合并过敏且服用地氯雷他定的患者治疗OAB的有效率为90.14%，显著高于未服用地氯雷他定的患者，且血IgE水平是地氯雷他定治疗无效的危险因素。
结论
儿童OAB与过敏相关，地氯雷他定可有效改善OAB症状。
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