Li Peng, Chen Mei, Wang Daobin, Zhang Xue, Sun Ruiyang, Jia Wanyu, Fu Shuqin, Cui Junhao, Song Chunlan
Pediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, China.
Pediatric Emergency Department, Henan Provincial Engineering Research Center for Diagnosis and Treatment of Pediatric Infections and Critical Illnesses, Zhengzhou, Henan Province, China.
Front Pediatr. 2024 Oct 23;12:1418499. doi: 10.3389/fped.2024.1418499. eCollection 2024.
To retrospectively analyze the clinical characteristics and independent risk factors of severe influenza combined with febrile seizures, and to provide more basis for early clinical intervention.
A total of 161 children with severe influenza were collected as study subjects and divided into convulsive (FC) group (40 cases) and non-convulsive (NFC) group (121 cases) according to whether they had febrile seizures. The demographic characteristics and clinical data of the two groups were analyzed. Multivariate logistic regression was used to analyze the risk factors of severe influenza combined with febrile seizures. The predictive efficacy was evaluated by receiver operating characteristic (ROC) curve analysis.
(1) Multiple logistic regression analysis revealed that C-reactive protein (CRP) levels, Serum interleukin 6 (IL-6) levels, Days from onset of Flu symptoms to hospitalization, cerebrospinal fluid protein (CSF-TP) levels and the influenza virus type A (FluA) infection rate were found to be independent risk factors for severe influenza combined with febrile seizures in children. (2) ROC curve analysis showed that the cut-off value of CRP, Serum IL-6, Days from onset of Flu symptoms to hospitalization and CSF-TP were 7.57 mg/L, 9.84 pg/ml, 4.5 days and 194.8 mg/L, respectively.
Children with severe influenza with CRP ≥ 7.57 mg/L, Serum IL-6 ≥ 9.84 pg/ml, Days from onset of Flu symptoms to hospitalization ≤4.5 days, CSF-TP ≥ 194.8 mg/L and FluA had a significantly increased risk of febrile seizures. It is useful for clinicians to determine the risk of severe influenza combined with febrile seizures, to adjust the early treatment plan, and to reduce the incidence of critically ill patients.
回顾性分析重症流感合并热性惊厥的临床特征及独立危险因素，为临床早期干预提供更多依据。
收集161例重症流感患儿作为研究对象，根据是否发生热性惊厥分为惊厥组（40例）和非惊厥组（121例）。分析两组的人口学特征和临床资料。采用多因素logistic回归分析重症流感合并热性惊厥的危险因素。通过受试者工作特征（ROC）曲线分析评估预测效能。
（1）多因素logistic回归分析显示，C反应蛋白（CRP）水平、血清白细胞介素6（IL-6）水平、流感症状出现至住院天数、脑脊液蛋白（CSF-TP）水平及甲型流感病毒（FluA）感染率是儿童重症流感合并热性惊厥的独立危险因素。（2）ROC曲线分析显示，CRP、血清IL-6、流感症状出现至住院天数及CSF-TP的截断值分别为7.57mg/L、9.84pg/ml、4.5天和194.8mg/L。
CRP≥7.57mg/L、血清IL-6≥9.84pg/ml、流感症状出现至住院天数≤4.5天、CSF-TP≥194.8mg/L且感染FluA的重症流感患儿发生热性惊厥的风险显著增加。这有助于临床医生判断重症流感合并热性惊厥的风险，调整早期治疗方案，降低重症患者的发生率。
