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血管内动脉瘤修复术与开放手术修复术治疗腹主动脉瘤的比较

Endovascular Aneurysm Repair Versus Open Surgical Repair in Treating Abdominal Aortic Aneurysm.

作者信息

Vienneau James R, Burns Camden I, Boghokian Anto, Soti Varun

机构信息

Surgery, Lake Erie College of Osteopathic Medicine, Erie, USA.

Anesthesiology, Lake Erie College of Osteopathic Medicine, Elmira, USA.

出版信息

Cureus. 2024 Nov 5;16(11):e73066. doi: 10.7759/cureus.73066. eCollection 2024 Nov.

Abstract

Abdominal aortic aneurysm (AAA) denotes an abdominal aorta dilation exceeding 3 cm, typically asymptomatic until rupture, posing severe consequences, including fatality. Therefore, continual screening is imperative, and surgical intervention is recommended upon reaching a diameter of 5.5 cm to prevent rupture. The primary surgical approaches are open surgical repair or open repair (OR) and endovascular aneurysm repair (EVAR). This review juxtaposes EVAR's short- and long-term effectiveness, safety, and perioperative complications in AAA patients versus OR, elucidating clinical benefits and avenues for further research. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, an extensive literature review was conducted using the PubMed and Clinicaltrials.gov databases. The review specifically focused on clinical studies directly comparing EVAR versus OR. The comprehensive literature review revealed that EVAR confers a survival advantage for up to four years post-procedure. However, the benefit shifts to OR after four to eight years due to aneurysm-related complications, such as ruptures, underscoring the necessity of lifelong post-EVAR monitoring. Following EVAR, AAA patients necessitate significantly more frequent secondary interventions due to graft-related issues, including endoleaks, thereby escalating long-term complexity and care costs. Conversely, following OR, a notably higher proportion of patients require mechanical ventilation and blood transfusions and experience prolonged intensive-care and mid-care unit stays, consequently extending hospitalization. After EVAR, patients recover substantially faster, returning to normal activities sooner. Nonetheless, the long-term quality of life between the two procedures becomes comparable. While EVAR presents itself as a less invasive alternative to OR, especially for high surgical risk patients, the imperative of long-term surveillance and the risk of secondary interventions pose significant challenges. Advancements in EVAR technology and technique are broadening its utility. Yet, continual research is crucial to optimize patient selection, improve long-term outcomes, and ensure that EVAR's benefits outweigh the risks. Therefore, choosing EVAR over OR in treating AAA patients must factor in a patient's overall health, anatomical considerations, and the probability of long-term success.

摘要

腹主动脉瘤(AAA)是指腹主动脉直径扩张超过3厘米,通常在破裂前无症状,但破裂会带来严重后果,包括死亡。因此,持续筛查至关重要,建议在直径达到5.5厘米时进行手术干预以防止破裂。主要的手术方法是开放手术修复或开放式修复(OR)以及血管内动脉瘤修复(EVAR)。本综述将EVAR与OR在AAA患者中的短期和长期有效性、安全性及围手术期并发症进行了对比,阐明了临床益处及进一步研究的方向。按照系统评价和Meta分析的首选报告项目指南,使用PubMed和Clinicaltrials.gov数据库进行了广泛的文献综述。该综述特别关注直接比较EVAR与OR的临床研究。全面的文献综述显示,EVAR在术后四年内具有生存优势。然而,由于动脉瘤相关并发症(如破裂),四至八年后优势转向OR,这突出了EVAR术后终身监测的必要性。EVAR术后,由于与移植物相关的问题(包括内漏),AAA患者需要更频繁的二次干预,从而增加了长期复杂性和护理成本。相反,OR术后,需要机械通气和输血的患者比例明显更高,且在重症监护病房和中级护理病房的住院时间延长,从而延长了住院时间。EVAR术后,患者恢复得更快,更快恢复正常活动。尽管如此,两种手术的长期生活质量变得相当。虽然EVAR是一种比OR侵入性更小的替代方案,特别是对于高手术风险患者,但长期监测的必要性和二次干预的风险带来了重大挑战。EVAR技术和技巧的进步正在扩大其应用范围。然而,持续研究对于优化患者选择、改善长期结果以及确保EVAR的益处超过风险至关重要。因此,在治疗AAA患者时选择EVAR而非OR必须考虑患者的整体健康状况、解剖学因素以及长期成功的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4cb/11540110/9ffa4054386d/cureus-0016-00000073066-i01.jpg

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