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Exclusively plant, whole-food diet for polypharmacy due to persistent atrial fibrillation, ischaemic cardiomyopathy, hyperlipidaemia and hypertension in an octogenarian.一位八旬老人因持续性房颤、缺血性心肌病、高脂血症和高血压而服用多种药物,采用纯植物全食物饮食。
BMJ Case Rep. 2018 Dec 17;11(1):e227059. doi: 10.1136/bcr-2018-227059.
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本文引用的文献

1
Deprescribing in primary care in Portugal (DePil17-20): a three-phase observational and experimental study protocol.葡萄牙初级保健中的减药方案(DePil17-20):一项三阶段观察性和实验研究方案。
BMJ Open. 2018 Jul 17;8(7):e019542. doi: 10.1136/bmjopen-2017-019542.
2
Effectiveness of blood pressure-lowering drug treatment by levels of absolute risk: post hoc analysis of the Australian National Blood Pressure Study.根据绝对风险水平进行降压药物治疗的有效性:澳大利亚国家血压研究的事后分析
BMJ Open. 2018 Mar 19;8(3):e017723. doi: 10.1136/bmjopen-2017-017723.
3
Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association.《2018年心脏病和中风统计数据更新:美国心脏协会报告》
Circulation. 2018 Mar 20;137(12):e67-e492. doi: 10.1161/CIR.0000000000000558. Epub 2018 Jan 31.
4
A plant-based diet for overweight and obesity prevention and treatment.一种用于预防和治疗超重与肥胖的植物性饮食。
J Geriatr Cardiol. 2017 May;14(5):369-374. doi: 10.11909/j.issn.1671-5411.2017.05.002.
5
The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes.BROAD研究:一项在社区中使用全植物性食物饮食治疗肥胖、缺血性心脏病或糖尿病的随机对照试验。
Nutr Diabetes. 2017 Mar 20;7(3):e256. doi: 10.1038/nutd.2017.3.
6
Deprescribing: a new goal focused on the patient.减药:以患者为中心的新目标。
Expert Opin Drug Saf. 2017 Feb;16(2):111-112. doi: 10.1080/14740338.2017.1273347. Epub 2016 Dec 26.
7
Vegetarian diet reduces the risk of hypertension independent of abdominal obesity and inflammation: a prospective study.素食饮食可独立于腹型肥胖和炎症降低高血压风险:一项前瞻性研究。
J Hypertens. 2016 Nov;34(11):2164-71. doi: 10.1097/HJH.0000000000001068.
8
Vegetarian Diets and Weight Reduction: a Meta-Analysis of Randomized Controlled Trials.素食饮食与体重减轻:随机对照试验的荟萃分析
J Gen Intern Med. 2016 Jan;31(1):109-16. doi: 10.1007/s11606-015-3390-7.
9
Polypharmacy: a global risk factor for elderly people.多重用药:老年人面临的一个全球性风险因素。
J Int Oral Health. 2014 Nov-Dec;6(6):i-ii.
10
Polypharmacy in the Elderly: A Marker of Increased Risk of Mortality in a Population-Based Prospective Study (NEDICES).老年人多重用药:一项基于人群的前瞻性研究(NEDICES)中死亡率增加风险的标志物
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一位八旬老人因持续性房颤、缺血性心肌病、高脂血症和高血压而服用多种药物,采用纯植物全食物饮食。

Exclusively plant, whole-food diet for polypharmacy due to persistent atrial fibrillation, ischaemic cardiomyopathy, hyperlipidaemia and hypertension in an octogenarian.

作者信息

Beauchesne Andrew B, Goldhamer Alan C, Myers Toshia R

机构信息

Tufts University School of Medicine, Boston, Massachusetts, USA.

Nutritional Medicine, TrueNorth Health Center, Santa Rosa, California, USA.

出版信息

BMJ Case Rep. 2018 Dec 17;11(1):e227059. doi: 10.1136/bcr-2018-227059.

DOI:10.1136/bcr-2018-227059
PMID:30567282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6301550/
Abstract

Polypharmacy is common and associated with negative health outcomes in the elderly. We report the case of an 82-year-old man with a history of polypharmacy due to coronary artery disease, myocardial infarction, ischaemic cardiomyopathy, hyperlipidaemia, hypertension and persistent atrial fibrillation who presented with memory loss, cognitive impairment, fatigue and weakness. His treatment plan included an exclusively plant, whole-food diet and moderate physical activity which resulted in a rapid reduction of hyperlipidaemia and high blood pressure and the discontinuation of statin, antihypertensive and beta blocker drug therapy. The patient also reported reversal of impaired cognition and symptoms associated with atrial fibrillation and ischaemic cardiomyopathy, including light-headedness, fatigue and weakness. This case demonstrates that dietary and lifestyle modifications have the potential to improve symptoms of cardiovascular disease and reduce polypharmacy along with associated negative consequences in the elderly.

摘要

多重用药在老年人中很常见,且与不良健康后果相关。我们报告一例82岁男性病例,该患者因冠状动脉疾病、心肌梗死、缺血性心肌病、高脂血症、高血压和持续性心房颤动而有多重用药史,出现了记忆力减退、认知障碍、疲劳和虚弱症状。他的治疗方案包括完全基于植物的全食物饮食和适度体育活动,这导致高脂血症和高血压迅速减轻,他汀类药物、抗高血压药物和β受体阻滞剂药物治疗停用。患者还报告认知障碍以及与心房颤动和缺血性心肌病相关的症状(包括头晕、疲劳和虚弱)得到了逆转。该病例表明,饮食和生活方式的改变有可能改善心血管疾病症状,并减少老年人的多重用药及其相关不良后果。