小分子热休克蛋白磷酸化之谜。 - Suppr

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The enigma of small heat shock protein phosphorylation.

作者信息

Gaestel Matthias

机构信息

Hannover Medical School, Institute of Cell Biochemistry, Hannover, Germany.

出版信息

Front Pharmacol. 2024 Oct 23;15:1486245. doi: 10.3389/fphar.2024.1486245. eCollection 2024.

DOI:10.3389/fphar.2024.1486245

PMID:39508045

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11538052/

Abstract

摘要

相似文献

The enigma of small heat shock protein phosphorylation.小分子热休克蛋白磷酸化之谜。

Front Pharmacol. 2024 Oct 23;15:1486245. doi: 10.3389/fphar.2024.1486245. eCollection 2024.

MAPKAP kinase 2 is activated by heat shock and TNF-alpha: in vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade.丝裂原活化蛋白激酶相关激酶2可被热休克和肿瘤坏死因子-α激活：小热休克蛋白的体内磷酸化源于丝裂原活化蛋白激酶级联反应的刺激。

J Cell Biochem. 1995 Feb;57(2):321-30. doi: 10.1002/jcb.240570216.

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.丝裂原活化蛋白激酶相关蛋白激酶2对小热休克蛋白Hsp25的应激和丝裂原诱导的磷酸化对于伴侣蛋白特性和细胞热耐受性并非必不可少。

EMBO J. 1994 Jan 1;13(1):54-60. doi: 10.1002/j.1460-2075.1994.tb06234.x.

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.通过磷酸化对热休克蛋白27（Hsp27）寡聚化、伴侣功能及抗氧化应激/肿瘤坏死因子α保护活性的调控

J Biol Chem. 1999 Jul 2;274(27):18947-56. doi: 10.1074/jbc.274.27.18947.

Small heat-shock protein family: function in health and disease.小热休克蛋白家族：在健康与疾病中的功能

Ann N Y Acad Sci. 1998 Jun 30;851:28-35. doi: 10.1111/j.1749-6632.1998.tb08973.x.

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.

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High expression and activation of MAP kinase-activated protein kinase 2 in cardiac muscle cells.心肌细胞中丝裂原活化蛋白激酶激活的蛋白激酶2的高表达与激活

J Mol Cell Cardiol. 1997 Aug;29(8):2159-68. doi: 10.1006/jmcc.1997.0449.

Small heat shock proteins (sHSPs) as potential drug targets.小热休克蛋白（sHSPs）作为潜在的药物靶点。

Curr Pharm Biotechnol. 2001 Mar;2(1):77-111. doi: 10.2174/1389201013378833.

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.一种由应激和热休克触发的新型激酶级联反应，可刺激丝裂原活化蛋白激酶相关蛋白激酶-2以及小热休克蛋白的磷酸化。

Cell. 1994 Sep 23;78(6):1027-37. doi: 10.1016/0092-8674(94)90277-1.

Chaperone function of two small heat shock proteins from maize.玉米中两种小热休克蛋白的伴侣功能。

Plant Sci. 2014 May;221-222:48-58. doi: 10.1016/j.plantsci.2014.01.012. Epub 2014 Feb 6.

本文引用的文献

Potential for targeting small heat shock protein modifications.靶向小分子热休克蛋白修饰的潜力。

Trends Pharmacol Sci. 2024 Jul;45(7):583-585. doi: 10.1016/j.tips.2024.04.002. Epub 2024 May 3.

MAPK-Activated Protein Kinases: Servant or Partner?丝裂原活化蛋白激酶：仆人还是伙伴？

Annu Rev Biochem. 2022 Jun 21;91:505-540. doi: 10.1146/annurev-biochem-081720-114505. Epub 2022 Mar 18.

Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.选择性抑制 p38α MAPK-MK2 轴可抑制炎症信号，包括炎症小体的激活信号。

J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16.

MK2 balances inflammation and cell death.MK2 平衡炎症和细胞死亡。

Nat Cell Biol. 2017 Sep 29;19(10):1150-1152. doi: 10.1038/ncb3619.

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation.RNA结合蛋白TTP是炎症中反馈控制的全局转录后调节因子。

Nucleic Acids Res. 2016 Sep 6;44(15):7418-40. doi: 10.1093/nar/gkw474. Epub 2016 May 24.

Heat shock protein B1-deficient mice display impaired wound healing.热休克蛋白 B1 缺乏小鼠表现出伤口愈合受损。

PLoS One. 2013 Oct 15;8(10):e77383. doi: 10.1371/journal.pone.0077383. eCollection 2013.

Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.在基因靶向敲除小鼠模型中对小分子热休克蛋白25（HSPB1）的功能及调控机制的深入研究

Genesis. 2007 Aug;45(8):487-501. doi: 10.1002/dvg.20319.

Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress.丝裂原活化蛋白激酶2（MK2）缺陷细胞中小热休克蛋白Hsp25的特性分析：Hsp25寡聚体的MK2依赖性不溶性与应激易感性相关。

J Biol Chem. 2006 Sep 15;281(37):26966-75. doi: 10.1074/jbc.M602134200. Epub 2006 Jul 13.

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.丝裂原活化蛋白激酶激活的蛋白激酶2对脂多糖诱导的肿瘤坏死因子-α生物合成至关重要。

Nat Cell Biol. 1999 Jun;1(2):94-7. doi: 10.1038/10061.

J Biol Chem. 1999 Jul 2;274(27):18947-56. doi: 10.1074/jbc.274.27.18947.

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