Department of Biomedical Engineering, The Pennsylvania State University, PA, USA.
Department of Biomedical Engineering, The Pennsylvania State University, PA, USA; Institute for Computational and Data Sciences, The Pennsylvania State University, PA, USA.
Neuroimage. 2024 Nov 15;302:120905. doi: 10.1016/j.neuroimage.2024.120905. Epub 2024 Oct 24.
Cerebrospinal fluid (CSF) flow may assist the clearance of brain wastes, such as amyloid-β (Aβ) and tau, and thus play an important role in aging and dementias. However, a lack of non-invasive tools to assess the CSF dynamics-related clearance in humans hindered the understanding of the relevant changes in healthy aging. The global infra-slow (<0.1 Hz) brain activity measured by the global mean resting-state fMRI signal (gBOLD) was recently found to be coupled by large CSF movements. This coupling has been found to correlate with various pathologies of Alzheimer's disease (AD), particularly Aβ pathology, linking it to waste clearance. Using resting-state fMRI data from a group of 719 healthy aging participants, we examined the sex-specific differences of the gBOLD-CSF coupling over a wide age range between 36-100 years of age. We found that this coupling index remains stable before around age 55 and then starts to decline afterward, particularly in females. Menopause may contribute to the accelerated decline in females.
脑脊液（CSF）流动可能有助于清除大脑废物，如淀粉样蛋白-β（Aβ）和 tau，因此在衰老和痴呆中发挥着重要作用。然而，由于缺乏非侵入性工具来评估人类 CSF 动力学相关的清除率，因此阻碍了对健康衰老相关变化的理解。最近发现，通过全局静息状态 fMRI 信号（gBOLD）测量的全球亚慢波（<0.1 Hz）大脑活动与大量 CSF 运动耦合。这种耦合已被发现与阿尔茨海默病（AD）的各种病理相关，特别是 Aβ 病理，将其与废物清除联系起来。使用来自 719 名健康衰老参与者的静息状态 fMRI 数据，我们在 36-100 岁的广泛年龄范围内，检查了 gBOLD-CSF 耦合在性别特异性上的差异。我们发现，这个耦合指数在大约 55 岁之前保持稳定，然后开始下降，特别是在女性中。绝经期可能导致女性下降加速。
