Ophthalmology Department, World Eye Hospital, Ankara, Turkey.
Ophthalmology Department, Bishkek Kudret Eye Hospital, Bishkek, Kyrgyzstan.
Int Ophthalmol. 2024 Nov 7;44(1):415. doi: 10.1007/s10792-024-03343-y.
To evaluate the retinal vasculature in patient with internal carotid artery (ICA) stenosis and to highlight association between ICA stenosis severity and retinal vasculature changes.
Seventy-five subjects were included in this prospective study. Twenty-five healthy subjects were included in the Group 1, 25 subjects with 1-49% ICA stenosis were included in the Group 2, and 25 subjects with 50-69% ICA stenosis were included in the Group 3. Visual acuity, intraocular pressure (IOP), and anterior and posterior segment examinations were performed. Macular superficial and deep capillary density, optic nerve head capillary density, and choroidal thickness data were measured using optic coherence tomography angiography.
There was a statistically significant difference between the three groups regarding superficial vascular density, deep vascular density, vascular density of radial peripapillary capillary and choroid thickness (p < 0.05 for all). Mean parafoveal and perifoveal area vascular density of the superficial capillary plexus was significantly lower in the Group 3 than Group 1 (p < 0.05 for all). Mean whole area vascular density of the deep capillary plexus was significantly lower in Group 3 than both groups (p < 0.05 for all). Mean parafoveal area vascular density of the deep capillary plexus was significantly lower in the Group 3 than Group 1 (p < 0.05). Mean subfoveal choroid thickness in group 3 was significantly lower in the Group 3 than both groups (p < 0.05 for all).
Compared to healthy controls, patients with moderate ICA stenosis revealed decreased density of superficial, deep and radial peripapillary capillary vasculature and subfoveal choroidal thickness.
评估颈内动脉（ICA）狭窄患者的视网膜血管，并强调 ICA 狭窄严重程度与视网膜血管变化之间的关系。
本前瞻性研究纳入了 75 名受试者。25 名健康受试者纳入第 1 组，25 名 ICA 狭窄 1-49%的受试者纳入第 2 组，25 名 ICA 狭窄 50-69%的受试者纳入第 3 组。检查视力、眼压（IOP）以及眼前段和眼后段。使用光相干断层扫描血管造影术测量黄斑浅层和深层毛细血管密度、视神经头毛细血管密度和脉络膜厚度数据。
三组之间在浅层血管密度、深层血管密度、放射状视神经周围毛细血管血管密度和脉络膜厚度方面存在统计学显著差异（所有 p 值均<0.05）。第 3 组的黄斑旁和中心凹旁浅层毛细血管丛的平均视盘旁区和中心凹区血管密度明显低于第 1 组（所有 p 值均<0.05）。第 3 组的深层毛细血管丛的全区域血管密度明显低于两组（所有 p 值均<0.05）。第 3 组的深层毛细血管丛的黄斑旁区血管密度明显低于第 1 组（p<0.05）。第 3 组的黄斑下脉络膜厚度明显低于两组（所有 p 值均<0.05）。
与健康对照组相比，中度 ICA 狭窄患者的浅层、深层和放射状视神经周围毛细血管血管密度以及黄斑下脉络膜厚度降低。
