埃塞俄比亚医护人员乙型和丙型病毒性肝炎感染的血清流行率：系统评价和荟萃分析。
Seroprevalence of viral hepatitis B and C infections among healthcare workers in Ethiopia: A systematic review and meta-analysis.
机构信息
Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Medical Microbiology, School of Biomedical and Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
PLoS One. 2024 Nov 7;19(11):e0312959. doi: 10.1371/journal.pone.0312959. eCollection 2024.
BACKGROUND
Healthcare workers (HCWs) are at higher risk of contracting hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Currently, there is no estimate of pooled data on the prevalence of HBV and HCV infections among HCWs in the country. Thus, this review aimed to determine the pooled prevalence of hepatitis B and C infections among HCWs in Ethiopia.
MATERIALS AND METHODS
A comprehensive literature search was conducted using electronic databases, including PubMed, Cochrane Library, Science Direct, Hinari, and African Journals Online to identify pertinent articles from the inception to April 2024. The protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42024527940) and conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were extracted independently by two authors and analyzed using STATA version 11 software. A random-effect model and Egger's test were computed to estimate the pooled prevalence and assess publication bias, respectively.
RESULTS
A total of 18 studies involving4,948 healthcare workers were included in this review to estimate the pooled prevalence of HBV and HCV infections among HCWs in Ethiopia. The overall prevalence of HBV was 5.93% (95% CI; 3.22-8.63). The sub-group analysis showed that the prevalence of HBV among medical waste handlers and health professionals was8.6% (95% CI; 3.01-14.13) and 4.98% (95% CI; 1.85-8.11), respectively. The combined prevalence of HCV was 1.12% (95% CI; -4.19-6.43). In the sub-group analysis, the prevalence of HCV among medical waste handlers and health professionals was1.44% (95% CI; -5.28-8.18) and 0.59% (95% CI; -8.09-9.27), respectively.
CONCLUSION
In this review, we found a higher (5.93%) and moderate (1.12%) prevalence of HBV and HCV infections, respectively among Ethiopian HCWs. Therefore, to reduce the infectious burden of HBV and HCV among HCWs; there is a need to strict adherence to infection prevention and control measures. In addition, adequate HBV vaccination coverage for HCWs is mandatory to reduce the burden of HBV infection in the country.
背景
医护人员（HCWs）感染乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的风险更高。目前，尚无该国医护人员 HBV 和 HCV 感染患病率的汇总数据估计。因此，本综述旨在确定埃塞俄比亚医护人员中乙型肝炎和丙型肝炎感染的患病率。
材料和方法
使用电子数据库（包括 PubMed、Cochrane 图书馆、Science Direct、Hinari 和 African Journals Online）全面检索文献，以确定从成立到 2024 年 4 月的相关文章。该方案已在国际前瞻性系统评价注册中心（PROSPERO；CRD42024527940）中注册，并按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。两位作者独立提取数据，并使用 STATA 版本 11 软件进行分析。使用随机效应模型和 Egger 检验分别计算汇总患病率和评估发表偏倚。
结果
本综述共纳入 18 项研究，涉及 4948 名医护人员，以估计埃塞俄比亚医护人员中 HBV 和 HCV 感染的汇总患病率。HBV 的总体患病率为 5.93%（95%CI；3.22-8.63）。亚组分析显示，医疗废物处理人员和卫生专业人员的 HBV 患病率分别为 8.6%（95%CI；3.01-14.13）和 4.98%（95%CI；1.85-8.11）。HCV 的合并患病率为 1.12%（95%CI；-4.19-6.43）。在亚组分析中，医疗废物处理人员和卫生专业人员的 HCV 患病率分别为 1.44%（95%CI；-5.28-8.18）和 0.59%（95%CI；-8.09-9.27）。
结论
在本综述中，我们发现埃塞俄比亚 HCWs 中 HBV 和 HCV 感染的患病率较高（分别为 5.93%和 1.12%），感染程度中等。因此，为了降低 HCWs 中 HBV 和 HCV 的感染负担；需要严格遵守感染预防和控制措施。此外，必须为 HCWs 提供足够的乙型肝炎疫苗接种覆盖率，以减轻该国的 HBV 感染负担。
Zotero 插件