Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan; Department of Psychiatry, Nara Medical University School of Medicine, Nara, Japan.
Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan; Department of Psychiatry, Nara Medical University School of Medicine, Nara, Japan.
Curr Opin Neurobiol. 2024 Dec;89:102932. doi: 10.1016/j.conb.2024.102932. Epub 2024 Nov 6.
Individuals with autism spectrum disorder (ASD) are more likely to experience adverse childhood experiences (ACEs) compared with typically developing (TD) individuals, which predisposes them to an elevated risk of mental health issues. This review elucidates the profound impact of ACEs on individuals with ASD by synthesizing findings from a plethora of epidemiologic and biological studies, encompassing genetics, epigenetics, and neuroimaging. Despite the limited number of studies explicitly focusing on this intersection, the extant literature consistently demonstrates that ASD individuals are disproportionately affected by ACEs, leading to significant deterioration in mental health and brain function. Furthermore, the nature and extent of the effects of ACEs appear to diverge between ASD and TD populations, underscoring the necessity for tailored clinical and research approaches. Understanding these complex and intertwined interactions is imperative for advancing both clinical practice and research, with the goal of mitigating the adverse outcomes associated with ACEs in ASD individuals.
自闭症谱系障碍（ASD）个体比典型发育（TD）个体更有可能经历不良的童年经历（ACEs），这使他们更容易出现心理健康问题。本综述通过综合大量流行病学和生物学研究的发现，包括遗传学、表观遗传学和神经影像学，阐明了 ACEs 对 ASD 个体的深远影响。尽管专门关注这一交叉点的研究数量有限，但现有文献一致表明，ASD 个体受到 ACEs 的不成比例影响，导致心理健康和大脑功能显著恶化。此外，ACEs 的影响的性质和程度在 ASD 和 TD 人群之间似乎存在差异，这突出了需要针对 ASD 人群采用量身定制的临床和研究方法。理解这些复杂和相互交织的相互作用对于推进临床实践和研究至关重要，目的是减轻 ASD 个体 ACEs 相关的不良后果。
