Zhang Haiqiong, Ren Chao, Liu Yu, Yan Xinchun, Liu Meixi, Hao Zhixin, Xing Haiqun, Huo Li
Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
J Nucl Med. 2024 Dec 3;65(12):1974-1982. doi: 10.2967/jnumed.124.267963.
The uMI Panorama GS PET/CT system is a new long-axial-field-of-view scanner featuring high sensitivity, time-of-flight (TOF) resolution, spatial resolution, and count rate performance. The aim of this study is to assess the PET system on the basis of the National Electrical Manufacturers Association (NEMA) NU 2-2018 and European Association of Nuclear Medicine Research Limited (EARL) standards. Spatial resolution, count rate performance, sensitivity, accuracy, image quality, TOF resolution, and coregistration accuracy were evaluated following the NEMA NU 2-2018 standard. Additional experiments included energy resolution, 200-cm-long line sources for sensitivity, a 175-cm-long scatter phantom for count rate and TOF resolution, as well as the compliance with the EARL guideline. Moreover, an F-FDG PET patient study was reconstructed with various frame durations. The PET system achieved sub-3-mm transaxial and axial spatial resolutions at a 1-cm radial offset. The sensitivities with the 70-cm-long and 200-cm-long line sources were observed to be 176.3 and 90.8 kcps/MBq, respectively, at the center of the field of view. The noise-equivalent count rates (NECRs) of the 70-cm-long and 175-cm-long scatter phantoms were measured to be 3.35 Mcps at 57.57 kBq/mL and 2.24 Mcps at 33.27 kBq/mL, respectively. The TOF resolutions for both phantoms were approximately 189 ps at 5.3 kBq/mL and lower than 200 ps below the NECR peaks. The absolute count rate errors of all 34 acquisitions were less than 3% below the NECR peak for the 70-cm-long scatter phantom. With the standard NEMA image quality phantom experiment, the contrast recovery coefficient varied from 68.17% to 94.20% and the background variabilities were all below 2%. The maximum PET/CT coregistration error was 1.33 mm. Regarding EARL compliance, the gaussian filter of 5-mm full width at half maximum could produce acceptable images. The patient data demonstrate visually satisfactory image quality with short frames (less than 1 min). The uMI Panorama GS exhibits spatial resolution and TOF resolution similar to those of the uMI Panorama system (35-cm axial field of view), despite the extended axial field of view. The 148-cm axial coverage, sub-200-ps TOF resolution, high sensitivity, and count rate performances are expected to yield superior image quality and offer new opportunities for various clinical applications.
uMI全景GS PET/CT系统是一款新型的长轴视野扫描仪，具有高灵敏度、飞行时间（TOF）分辨率、空间分辨率和计数率性能。本研究的目的是根据美国国家电气制造商协会（NEMA）NU 2-2018和欧洲核医学研究协会（EARL）标准对该PET系统进行评估。按照NEMA NU 2-2018标准评估了空间分辨率、计数率性能、灵敏度、准确性、图像质量、TOF分辨率和配准精度。额外的实验包括能量分辨率、用于灵敏度测量的200厘米长线源、用于计数率和TOF分辨率测量的175厘米长散射体模，以及是否符合EARL指南。此外，对一项F-FDG PET患者研究采用了不同的帧持续时间进行重建。该PET系统在1厘米径向偏移处实现了亚3毫米的横向和轴向空间分辨率。在视野中心，70厘米长线源和200厘米长线源的灵敏度分别为176.3和90.8 kcps/MBq。70厘米长和175厘米长散射体模的噪声等效计数率（NECR）在57.57 kBq/mL时分别测量为3.35 Mcps，在33.27 kBq/mL时为2.24 Mcps。两个体模在5.3 kBq/mL时的TOF分辨率约为189 ps，在NECR峰值以下低于200 ps。对于70厘米长的散射体模，在NECR峰值以下所有34次采集的绝对计数率误差均小于3%。在标准的NEMA图像质量体模实验中，对比度恢复系数在68.17%至94.20%之间变化，背景变化均低于2%。PET/CT的最大配准误差为1.33毫米。关于EARL合规性，半高宽为5毫米的高斯滤波器可以产生可接受的图像。患者数据表明，短帧（小于1分钟）时图像质量在视觉上令人满意。尽管轴向视野有所扩展，但uMI全景GS的空间分辨率和TOF分辨率与uMI全景系统（35厘米轴向视野）相似。148厘米的轴向覆盖范围、低于200 ps的TOF分辨率、高灵敏度和计数率性能有望产生卓越的图像质量，并为各种临床应用提供新的机会。
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