系统性红斑狼疮风险：环境因素的作用。

Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.

机构信息

McGill University, Montreal, Quebec, Canada.

Epidemiology Branch, Department of Health and Human Services, National Institutes of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

出版信息

Rheum Dis Clin North Am. 2022 Nov;48(4):827-843. doi: 10.1016/j.rdc.2022.06.005. Epub 2022 Oct 1.

DOI:10.1016/j.rdc.2022.06.005

PMID:36332998

Abstract

Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease. The etiology of SLE is multifactorial and includes potential environmental triggers, which may occur sequentially (the "multi-hit" hypothesis). This review focuses on SLE risk potentially associated with environmental factors including infections, the microbiome, diet, respirable exposures (eg, crystalline silica, smoking, air pollution), organic pollutants, heavy metals, and ultraviolet radiation.

摘要

系统性红斑狼疮（SLE）是一种复杂的慢性自身免疫性疾病。SLE 的病因是多因素的，包括潜在的环境触发因素，这些因素可能会依次发生（“多打击”假说）。本综述重点介绍了可能与环境因素相关的 SLE 风险，包括感染、微生物组、饮食、可吸入暴露（如结晶硅、吸烟、空气污染）、有机污染物、重金属和紫外线辐射。