Enjeti S, O'Neill J T, Terry P B, Menkes H A, Traystman R J
J Appl Physiol Respir Environ Exerc Physiol. 1979 Dec;47(6):1245-50. doi: 10.1152/jappl.1979.47.6.1245.
We studied the effects of sublobar atelectasis on regional blood flow in anesthetized paralyzed pigs. Following the washout of nitrogen from the lung with oxygen, a sublobar airway was obstructed and a peripheral segment of lung allowed to collapse. Blood flow to the atelectatic region fell from a control of 140.0 +/- 20.5 to 16.6 +/- 2.9 ml/(min . g). Basilar regions that became atelectatic spontaneously during the course of the studies had similar decreases in blood flow. Inflation of the surrounding lung by the application of positive end-expiratory pressure failed to increase blood flow and vascular conductance within the atelectatic regions. These results indicate that mechanical and hypoxic effects on vessels perfusing sublobar atelectatic regions limit the effects of interdependence from the surrounding lung. Furthermore, with inflation of the surrounding lung, increases in pulmonary shunting of blood are small.
我们研究了亚肺叶肺不张对麻醉瘫痪猪局部血流的影响。在用氧气冲洗肺内氮气后，阻塞一个亚肺叶气道，使肺的外周部分萎陷。流向肺不张区域的血流从对照时的140.0±20.5降至16.6±2.9毫升/（分钟·克）。在研究过程中自发出现肺不张的基底区域血流也有类似程度的减少。通过施加呼气末正压使周围肺膨胀，未能增加肺不张区域内的血流和血管传导性。这些结果表明，对灌注亚肺叶肺不张区域的血管的机械和缺氧作用限制了来自周围肺的相互依存效应。此外，随着周围肺的膨胀，肺内血液分流的增加很小。
