Occurrence, fate and control strategies of heavy metals and antibiotics in livestock manure compost land application: A review.

Composting is a sustainable method for managing livestock manure, but the residual heavy metals and antibiotics in the compost pose can pose environmental risks when applied to land. Although many studies focus on occurrence and risk mitigation of heavy metals and antibiotics in manure compost land application, there is a lack of systematic analysis covering the entire chain from source to process and final disposal. Given this, this article provides a comprehensive review of the sources, migration, fate, risk assessment, and risk reduction of heavy metals and antibiotics contamination in land application of livestock manure compost for the first time. The main pollutants of concern are heavy metals, particularly Cu and Zn, and antibiotics such as quinolones, tetracyclines, and sulfonamides. The coexistence of these contaminants can easily trigger co-contamination, threatening soil ecosystems and human health. Risk reduction strategies, emphasizing the use of additives during composting and phytoremediation after land application, are discussed. Challenges remain in understanding the interactions between heavy metals and antibiotics and developing effective strategies for mitigating co-contamination. Furthermore, the paper proposes the future prospects on the interactions study and the simultaneous control strategy of heavy metals and antibiotics contamination. It is expected to promote the whole process management of livestock manure and the control of heavy metal-antibiotic co-contamination in the future.