Tulp O L, Hansen C T, Michaelis O E
Physiol Behav. 1986 Jan;36(1):127-31. doi: 10.1016/0031-9384(86)90085-5.
The effects of isoenergetic sucrose and starch-based diets on thermogenesis were investigated in young adult, male, lean and corpulent SHR/N-cp rats. Corpulent rats gained weight 1.5 times more rapidly than lean, and sucrose diets resulted in more rapid weight gains in both phenotypes. Rates of resting and of norepinephrine-stimulated oxygen consumption were similar in both groups of lean rats and in sucrose-fed corpulent rats, but were decreased in starch-fed corpulent rats. The thermic response to injected norepinephrine occurred normally in all groups. Colonic and rectal temperatures were greater in lean than in corpulent rats. Acute cold exposure (5 degrees C) resulted in decreases in rectal but not colonic temperature in lean rats fed both diets, but resulted in lower temperatures at both sites in corpulent rats, with the greatest decreases being observed in the starch fed corpulent rats. Fifty percent of the corpulent but none of the lean rats succumbed within 24-48 hours following cold exposure. Urinary vanilmandelic acid (VMA) excretion was greater in lean than in corpulent rats, and the sucrose diet induced a greater increment in urinary VMA excretion in lean rats than in corpulent rats. These results are consistent with an impaired activation of sympathetically-mediated thermogenesis via nutritional or environmental stimuli in the corpulent genotype of the SHR/N-cp rat in concert with an economy in energy expenditure which may be contributing factors in the causation of their obese state.
在年轻成年雄性瘦型和肥胖型SHR/N-cp大鼠中，研究了等能量的蔗糖和淀粉基饮食对产热的影响。肥胖大鼠体重增加速度比瘦型大鼠快1.5倍，蔗糖饮食使两种表型的大鼠体重增加更快。两组瘦型大鼠以及蔗糖喂养的肥胖大鼠的静息和去甲肾上腺素刺激的耗氧率相似，但淀粉喂养的肥胖大鼠的耗氧率降低。所有组对注射去甲肾上腺素的热反应均正常。瘦型大鼠的结肠和直肠温度高于肥胖大鼠。急性冷暴露（5摄氏度）导致两种饮食喂养的瘦型大鼠直肠温度降低，但结肠温度未降低，而肥胖大鼠的两个部位温度均降低，在淀粉喂养的肥胖大鼠中观察到的降低幅度最大。50%的肥胖大鼠在冷暴露后24至48小时内死亡，而瘦型大鼠无一死亡。瘦型大鼠尿香草扁桃酸（VMA）排泄量高于肥胖大鼠，蔗糖饮食诱导瘦型大鼠尿VMA排泄量的增加幅度大于肥胖大鼠。这些结果与SHR/N-cp大鼠肥胖基因型中通过营养或环境刺激介导的交感神经产热激活受损以及能量消耗节约一致，这可能是导致其肥胖状态的因素。
