Zaidi H, Lamalmi N, Lahlou L, Slaoui M, Barkat A, Alamrani S, Alhamany Z
Mohammed V University, Faculty of Medicine and Pharmacy, 10170, Rabat, Morocco.
Laboratory of Pathological Anatomy and Cytology, Children's Hospital, CHU Ibn Sina, 10170, Rabat, Morocco.
Heliyon. 2020 Dec 16;6(12):e05698. doi: 10.1016/j.heliyon.2020.e05698. eCollection 2020 Dec.
Histological chorioamnionitis or "intrauterine inflammation or infection" (Triple I) it is an acute inflammation of amniotic membrane, chorionic plate and umbilical cord.
To assess in the event of the clinical predictive factors associated to histological chorioamnionitis.
Prospective examination of 50 placentas from aberrant pregnancies, and 50 placentas from 'normal' deliveries. The Placentas analyzed by the conventional histopathology method, and the severity of chorioamnionitis was classified histologically according to the intensity and the topography of placental inflammation.The clinical and histopathological features of the study groups were introduced into the SPSS 13 database (License University Mohammed V-Rabat).
36/50 placentas of aberrant pregnancies showed a histological chorioamnionitis often associated to a funisitis, and 11/50 normal placentas have shown some lesions of histological chorioamnionitis mainly grade one without funisitis.On the other hand we noted a statistically significant association between histological chorioamnionitis and premature rupture of the membranes (PROM) over than 12h (p < 0.001).
Our study confirmed the predominance of histological chorioamnionitis lesions in clinically suspected cases of chorioamnionitis with 72% versus 22% in the controls group.Among the clinical parameters studied, only the premature rupture of the Membranes was shown a statistically significant association with the appearance of histological signs of chorioamnionitis.In conclusion, chorioamnionitis is sometimes clinically silent. Morphological placental study could be a confirmation of this pathology, which is predominantly associated to PROM over than 12 h.
组织学绒毛膜羊膜炎或“宫内炎症或感染”（Triple I）是羊膜、绒毛膜板和脐带的急性炎症。
评估与组织学绒毛膜羊膜炎相关的临床预测因素。
对50例异常妊娠胎盘和50例“正常”分娩胎盘进行前瞻性检查。采用传统组织病理学方法分析胎盘，并根据胎盘炎症的强度和部位对绒毛膜羊膜炎的严重程度进行组织学分类。将研究组的临床和组织病理学特征录入SPSS 13数据库（穆罕默德五世大学-拉巴特许可）。
50例异常妊娠胎盘中，36例显示组织学绒毛膜羊膜炎，常伴有脐带炎；50例正常胎盘中，11例显示一些组织学绒毛膜羊膜炎病变，主要为一级，无脐带炎。另一方面，我们注意到组织学绒毛膜羊膜炎与胎膜早破（PROM）超过12小时之间存在统计学显著关联（p < 0.001）。
我们的研究证实，在临床疑似绒毛膜羊膜炎的病例中，组织学绒毛膜羊膜炎病变占主导，病例组为72%，对照组为22%。在所研究的临床参数中，只有胎膜早破与绒毛膜羊膜炎组织学征象的出现存在统计学显著关联。总之，绒毛膜羊膜炎有时在临床上无明显症状。胎盘形态学研究可证实这种病理情况，其主要与超过12小时的胎膜早破相关。
