Karlsson Mimmi, Ottosson Johan, Clarkson Spencer, Sjöberg Klas
Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden.
Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Int J Obes (Lond). 2025 Apr;49(4):612-618. doi: 10.1038/s41366-024-01675-4. Epub 2024 Nov 9.
More than 10% of the global population has a BMI above 35. Bariatric surgery is an efficient way to treat this condition. Unfortunately, there is a risk of nutritional deficiencies. The number of studies after a longer time span is scarce. The aim of this study was to determine the occurrence of anaemia five and ten years after bariatric surgery and how it was related to substitution therapy.
Registry data from individuals having primary bariatric surgery in the Scandinavian Obesity Surgery Registry (SOReg) from 2007 to 2022 and with a follow-up at five or ten years was retrieved. Demographic data including weight, as well as method of surgery, Hb levels, supplementation, PPI use and stomal ulcerations were recorded.
In total, 39,992 individuals (mean age 41 years, range 18-74, 77% women) could be included. The majority, 78%, had undergone laparoscopic Roux-en-Y gastric bypass. After five years, 2838/13,944 women (20.3%) and 456/4049 men (11.2%) had anaemia. After ten years, 644/3400 women (18.9%) and 178/947 men (18.8%) had anaemia. The use of oral iron increased from 40 to 45%, and the need for parenteral iron intake increased from 5 to 11%.
Anaemia is a significant but manageable condition five and ten years after bariatric surgery. Despite the prescription of oral iron supplements to 45% ten years after surgery, the Hb levels could still not be fully restored. Consequently, the importance of follow-up visits and continuous supplementation is emphasised.
全球超过10%的人口体重指数(BMI)高于35。减肥手术是治疗这种情况的有效方法。不幸的是,存在营养缺乏的风险。长期随访研究数量稀少。本研究的目的是确定减肥手术后五年和十年贫血的发生率及其与替代疗法的关系。
检索2007年至2022年在斯堪的纳维亚肥胖手术登记处(SOReg)接受初次减肥手术且有五年或十年随访记录的个体的登记数据。记录人口统计学数据,包括体重、手术方式、血红蛋白水平、补充剂使用情况、质子泵抑制剂(PPI)使用情况和吻合口溃疡情况。
总共纳入了39992名个体(平均年龄41岁,范围18 - 74岁,77%为女性)。大多数人(78%)接受了腹腔镜Roux-en-Y胃旁路手术。五年后,13944名女性中有2838名(20.3%)和4049名男性中有456名(11.2%)患有贫血。十年后,3400名女性中有644名(18.9%)和947名男性中有178名(18.8%)患有贫血。口服铁剂的使用从40%增加到45%,肠外铁剂摄入需求从5%增加到11%。
贫血是减肥手术后五年和十年的一个重要但可控制的情况。尽管术后十年有45%的患者服用了口服铁补充剂,但血红蛋白水平仍未完全恢复。因此,强调了随访和持续补充的重要性。