Luca Antonina, Luca Maria, Kasper Siegfried, Pecorino Basilio, Zohar Joseph, Souery Daniel, Montgomery Stuart, Ferentinos Panagiotis, Rujescu Dan, Messina Antonino, Zanardi Raffaella, Ferri Raffaele, Tripodi Mariangela, Baune Bernhard T, Fanelli Giuseppe, Fabbri Chiara, Mendlewicz Julien, Serretti Alessandro
Department of Medicine and Surgery, Kore University of Enna, Enna, Italy.
Centre for Addiction, Adrano-Bronte, Italy.
Int J Neuropsychopharmacol. 2024 Dec 1;27(12). doi: 10.1093/ijnp/pyae055.
Anhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonresponse to treatment. However, a detailed clinical profile of anhedonia in MDD is still lacking.
One thousand two hundred ninety-four patients with MDD were selected from the cross-sectional European multicenter Group for the Study of Resistant Depression study. Anhedonia was assessed through the Montgomery-Åsberg Depression Rating Scale anhedonia item "inability to feel." Clinical and demographic features were then analyzed.
The presence of anhedonia related to a distinct demographical (living alone) and clinical profile (thyroid diseases, diabetes, suicide risk, high number of previous depressive episodes, more severe MDD, and more frequent inpatient status). Furthermore, anhedonia was associated with nonresponse to treatment and treatment resistance, even after adjusting for confounding variables.
Our findings support the role of anhedonia as a modulating feature of MDD, being associated with a more severe depression profile. Moreover, anhedonic features are independent predictors of poor treatment response.
重度抑郁症（MDD）中的快感缺失特征与更差的病程和结局相关，并且可能预测对治疗无反应。然而，MDD中快感缺失的详细临床特征仍然缺乏。
从欧洲抗抑郁研究多中心横断面研究中选取1294例MDD患者。通过蒙哥马利-阿斯伯格抑郁评定量表中的快感缺失项目“无法感受”来评估快感缺失。然后分析临床和人口统计学特征。
快感缺失的存在与独特的人口统计学特征（独居）和临床特征（甲状腺疾病、糖尿病、自杀风险、既往抑郁发作次数多、MDD更严重以及住院状态更频繁）相关。此外，即使在调整混杂变量后，快感缺失仍与治疗无反应和治疗抵抗相关。
我们的研究结果支持快感缺失作为MDD调节特征的作用，与更严重的抑郁特征相关。此外，快感缺失特征是治疗反应不佳的独立预测因素。
