Assistance Publique-Hôpitaux de Marseille (AP-HM), 264 Rue Saint-Pierre, 13005, Marseille, France.
Assistance Publique-Hôpitaux de Marseille (AP-HM), 264 Rue Saint-Pierre, 13005, Marseille, France; IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France; Aix-Marseille Université, Microbes Evolution Phylogeny and Infections (MEPHI), 27 Boulevard Jean Moulin, 13005, Marseille, France.
J Clin Virol. 2024 Dec;175:105744. doi: 10.1016/j.jcv.2024.105744. Epub 2024 Nov 7.
We aimed to describe coinfections and iterative infections with respiratory viruses diagnosed over a 22-month period in 2021-2022 in public university hospitals of the second largest French city.
Respiratory virus infections were diagnosed by qPCR with the Fast Track Diagnostics Respiratory Pathogens 21 on nasopharyngeal swabs collected between 01/03/2021-31/10/2022 and sent for routine diagnosis purpose to our clinical microbiology-virology laboratory at public university hospitals of Marseille, Southern France.
Nasopharyngeal swabs from 17,689 patients were tested, of which 8,133 (46 %) were positive for ≥1 respiratory virus and 1,255 (15%) were co-infected with ≥2 viruses including 213 (2.6 %) with 3-7 viruses. Among them, 1,005 (80 %) were younger than 5 years, and mean age was significantly lower for coinfected than monoinfected patients (6.6 versus 23.8 years; p < 0.0001). Viruses with the highest confection rates were HBoV (97 %), HPeV (97 %), EV (92 %), ADV (68 %), and HCoV-HKU1 (63 %). Iterative infections were observed in 96 patients and they involved 10 different viruses.
Our study points out that coinfections with respiratory viruses vary over time in prevalence, involve majoritarily young children, and may involve concurrent acute infections or acute-on-chronic infections, which deserves further specific studies.
我们旨在描述 2021-2022 年期间在法国第二大城市的两所公立大学医院进行的为期 22 个月的呼吸道病毒合并感染和迭代感染。
通过 qPCR 使用 Fast Track Diagnostics Respiratory Pathogens 21 在 2021 年 3 月 1 日至 2022 年 10 月 31 日之间收集的鼻咽拭子上诊断呼吸道病毒感染，这些拭子被送往我们位于法国南部马赛公立大学医院的临床微生物学-病毒学实验室进行常规诊断。
共检测了 17689 名患者的鼻咽拭子，其中 8133 名（46%）至少感染了一种呼吸道病毒，1255 名（15%）合并感染了≥2 种病毒，包括 213 名（2.6%）感染了 3-7 种病毒。其中，1005 名（80%）患者年龄小于 5 岁，合并感染患者的平均年龄明显低于单感染患者（6.6 岁与 23.8 岁；p<0.0001）。混合感染率最高的病毒是 HBoV（97%）、HPeV（97%）、EV（92%）、ADV（68%）和 HCoV-HKU1（63%）。96 例患者出现迭代感染，涉及 10 种不同的病毒。
我们的研究表明，呼吸道病毒的合并感染在流行率上随时间变化，主要涉及幼儿，并且可能涉及同时发生的急性感染或急性加重的慢性感染，这值得进一步进行专门研究。
