Malafaia Andreia P, Sobreiro-Almeida Rita, Rodrigues João M M, Mano João F
Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.
Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.
Biomater Adv. 2025 Feb;167:214105. doi: 10.1016/j.bioadv.2024.214105. Epub 2024 Nov 5.
Over the last decade, 3D bioprinting has gained increasing popularity, being a technique capable of producing well-defined tissue-like structures. One of its most groundbreaking features is the ability to create personalized therapies tailored to the specific demands of individual patients. However, challenges including the selection of materials and crosslinking strategies, still need to be addressed to enhance ink characteristics and develop robust biomaterials. Herein, the authors showcase the potential of overcoming these challenges, focusing on the use of versatile, fast, and selective thiol-ene click chemistry to formulate inks for 3D bioprinting. The exploration of natural polymers, specifically proteins and polysaccharides, will be discussed and highlighted, outlining the advantages and disadvantages of this approach. Leveraging advanced thiol-ene click chemistry and natural polymers in the development of 3D printable bioinks may face the current challenges and is envisioned to pave the way towards innovative and personalized biomaterials for biomedical applications.
在过去十年中，3D生物打印越来越受欢迎，它是一种能够制造结构明确的类组织结构的技术。其最具开创性的特点之一是能够根据个体患者的特定需求创建个性化疗法。然而，包括材料选择和交联策略在内的挑战仍然需要解决，以提高墨水特性并开发坚固的生物材料。在此，作者展示了克服这些挑战的潜力，重点是使用通用、快速且具有选择性的硫醇-烯点击化学来制备用于3D生物打印的墨水。将讨论并强调对天然聚合物，特别是蛋白质和多糖的探索，概述这种方法的优缺点。在3D可打印生物墨水的开发中利用先进的硫醇-烯点击化学和天然聚合物可能会面临当前的挑战，但有望为生物医学应用中的创新和个性化生物材料铺平道路。
