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特发性颅内高压、自发性颅内低压与头痛:诊断与治疗的最新进展

IIH, SIH and headache: Diagnosis and treatment update.

作者信息

Wang Shuu-Jiun

机构信息

Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.

College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

出版信息

eNeurologicalSci. 2024 Oct 24;37:100532. doi: 10.1016/j.ensci.2024.100532. eCollection 2024 Dec.

Abstract

Idiopathic intracranial hypertension (IIH) and spontaneous intracranial hypotension (SIH) are two major secondary headache disorders resulting from abnormal intracranial pressure (ICP). This short communication outlines the pathophysiology, diagnostic criteria, and management strategies for IIH and SIH. IIH predominantly affects obese women of childbearing age and presents with daily headaches, visual disturbances, and papilledema. It is characterized by elevated cerebrospinal fluid (CSF) pressure, with diagnosis supported by imaging and lumbar puncture. Treatment includes weight reduction, medications, and surgical interventions in refractory cases. SIH, conversely, is caused by spontaneous spinal CSF leaks and presents with acute orthostatic headaches. Diagnosis is supported by neuroimaging and lumbar puncture, revealing low CSF pressure. Treatment includes supported care, (targeted) epidural blood patch, with surgical repair considered in refractory cases. Advances in imaging and treatment have significantly improved outcomes for both conditions.

摘要

特发性颅内高压(IIH)和自发性颅内低压(SIH)是由颅内压(ICP)异常引起的两种主要继发性头痛疾病。本短文概述了IIH和SIH的病理生理学、诊断标准及管理策略。IIH主要影响育龄肥胖女性,表现为每日头痛、视觉障碍和视乳头水肿。其特征为脑脊液(CSF)压力升高,影像学检查和腰椎穿刺有助于诊断。治疗包括减重、药物治疗,难治性病例需手术干预。相反,SIH由自发性脊髓脑脊液漏引起,表现为急性体位性头痛。神经影像学检查和腰椎穿刺有助于诊断,显示脑脊液压力降低。治疗包括支持性护理、(靶向)硬膜外血贴,难治性病例考虑手术修复。影像学和治疗方面的进展显著改善了这两种疾病的治疗效果。

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