2型免疫的最新进展。
Update on type 2 immunity.
作者信息
Gorska Magdalena M
机构信息
Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Health, Denver, and the Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colo.
出版信息
J Allergy Clin Immunol. 2025 Feb;155(2):327-335. doi: 10.1016/j.jaci.2024.11.003. Epub 2024 Nov 9.
This review article summarizes and comments on the mechanistic work on type 2 immunity published between January 2022 and September 2024. Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9, and IL-13 and is primarily known for its detrimental roles in allergic diseases and its protective roles in helminth infections. Other functions of type 2 immunity include protection against venoms and toxins, wound healing, tissue remodeling, regeneration, and metabolic homeostasis. This review article discusses novel findings on regulation of these processes and disease states by select cells and humoral factors of type 2 immunity, including group 2 innate lymphoid cells, CD4 T cells, mast cells, peripheral neurons, and IgE. The article also describes novel discoveries on regulation of these factors and cells by environmental exposures and the host. Further, the article discusses select genetic mouse models that were developed recently and have the potential to accelerate the field. Finally, the article comments on the significance of novel discoveries to clinical medicine, including drug development.
这篇综述文章总结并评论了2022年1月至2024年9月期间发表的关于2型免疫机制的研究工作。2型免疫的特征是产生白细胞介素-4、白细胞介素-5、白细胞介素-9和白细胞介素-13，主要因其在过敏性疾病中的有害作用以及在蠕虫感染中的保护作用而为人所知。2型免疫的其他功能包括抵御毒液和毒素、伤口愈合、组织重塑、再生以及代谢稳态。这篇综述文章讨论了2型免疫的特定细胞和体液因子（包括2型固有淋巴细胞、CD4 T细胞、肥大细胞、外周神经元和免疫球蛋白E）对这些过程和疾病状态调节的新发现。文章还描述了环境暴露和宿主对这些因子和细胞调节的新发现。此外，文章讨论了最近开发的、有可能加速该领域研究的特定基因小鼠模型。最后，文章评论了这些新发现对临床医学（包括药物开发）的意义。
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