Department of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine [Shaoxing Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University], Shaoxing, Zhejiang, China.
Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Front Endocrinol (Lausanne). 2024 Oct 28;15:1418766. doi: 10.3389/fendo.2024.1418766. eCollection 2024.
Physical activity (PA) plays an important role in human health. However, the relationship between the PA and dysthyreosis was not clear. This study aimed to explore this question.
We performed a population-based study on the basis of the participant's information that was collected from the National Health and Nutrition Examination Survey (NHANES) database. The association of the thyroid hormone and total PA metabolic equivalent task (MET) were assessed via linear regression analysis with adjusting for different covariates. Moreover, we also used path analysis to explore the causality between PA, thyroid hormone index, and dysthyreosis. The restricted cubic spline analysis was used to explore the non-linear relationship between the thyroid hormone index and the PA total MET.
A total of 2118 participants aged≥20, including 969 females and 1149 males, were collected from NHANES. The linear regression with multivariate adjustment suggested a linear relationship between the PA total MET and Thyroid-Stimulating Hormone Index (TSHI), and Thyroid Feedback Quantile-Based Index (TFQI), respectively. And TFQI and dysthyresis occurrence were significantly correlated (P<0.05). The path analysis showed that the PA total MET affected dysthyreosis occurrence by TFQI. In addition, we found a non-linear relationship between the total PA met and dysthyreosis via restricted cubic spline analysis.
PA was significantly correlated with dysthyreosis via thyroid hormone sensitivity. Therefore, it can be considered to prevent the occurrence of dysthyreosis by regulating thyroid hormone sensitivity through PA in daily life.
身体活动（PA）对人类健康起着重要作用。然而，PA 与甲状腺功能障碍之间的关系尚不清楚。本研究旨在探讨这一问题。
我们基于从国家健康和营养检查调查（NHANES）数据库中收集的参与者信息进行了一项基于人群的研究。通过线性回归分析评估甲状腺激素与总 PA 代谢当量任务（MET）之间的关联，并调整不同的协变量。此外，我们还使用路径分析来探讨 PA、甲状腺激素指标与甲状腺功能障碍之间的因果关系。使用限制立方样条分析来探讨甲状腺激素指标与 PA 总 MET 之间的非线性关系。
共纳入 2118 名年龄≥20 岁的参与者，包括 969 名女性和 1149 名男性，均来自 NHANES。多元调整后的线性回归表明，PA 总 MET 与促甲状腺激素指数（TSHI）和甲状腺反馈定量指数（TFQI）之间存在线性关系。此外，TFQI 与甲状腺功能障碍的发生显著相关（P<0.05）。路径分析显示，PA 总 MET 通过 TFQI 影响甲状腺功能障碍的发生。此外，通过限制立方样条分析发现，PA 总 MET 与甲状腺功能障碍之间存在非线性关系。
PA 通过甲状腺激素敏感性与甲状腺功能障碍显著相关。因此，通过日常生活中通过 PA 调节甲状腺激素敏感性，可以考虑预防甲状腺功能障碍的发生。
