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猪胶原基质和游离牙龈移植物用于软组织移植以增加种植体周围角化组织宽度的体积变化:一项回顾性临床研究。

Volumetric changes of porcine collagen matrix and free gingival grafts for soft-tissue grafting to increase the width of keratinized tissue around dental implants: a retrospective clinical study.

机构信息

Department of Oral Surgery and Implantology, Goethe-University Frankfurt, Carolinum, Frankfurt am Main, Germany.

Faculty of Medicine, Institute of Biostatistics and Mathematical Modelling, Goethe-University Frankfurt, Frankfurt am Main, Germany.

出版信息

Int J Implant Dent. 2024 Nov 12;10(1):52. doi: 10.1186/s40729-024-00575-6.

DOI:10.1186/s40729-024-00575-6
PMID:39531147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11557777/
Abstract

AIM

To compare three-dimensional changes of aporcine derived collagen matrix (CM) and free gingival grafts (FGG) for increasing keratinized tissue (KT) at dental implants over a 24-month follow-up period.

MATERIALS AND METHODS

This retrospective study enrolled 25 patients exhibiting 41 implants with deficient KT width (i.e., < 2 mm) who underwent soft tissue augmentation using either CM (11 patients/15 implants) or FGG (14 patients/26 implants). The primary outcome was tissue thickness change (mm) at treated implant sites between 1- (S0), 12- (S1), and 24-months (S2). Secondary outcome was the changes of KT width over a 24-month follow-up period.

RESULTS

Dimensional analyses from S0 to S1 and from S0 to S2 revealed a mean decrease in tissue thickness of -0.05 ± 0.35 mm and - 0.31 ± 0.41 mm in the CM group, and - 0.23 ± 0.38 mm and - 0.22 ± 0.81 mm in the FGG group, with no significant differences found between the groups (S0-S1: p = 0.14, S0-S2: p = 0.58). Within S1 and S2, the CM and FGG groups displayed comparable tissue thickness reduction (CM: -0.32 ± 0.53 mm, FGG: -0.02 ± 0.21 mm; p = 0.07). The FGG group exhibited a significantly greater KT gain 24-months compared to the CM group (CM: 1.50 ± 1.14 mm, FGG: 4.04 ± 1.65 mm; p < 0.001).

CONCLUSIONS

CM and FGG were associated with comparable three-dimensional thickness changes over a period of 24 months. A significantly wider KT band could be established in the FGG group.

摘要

目的

比较猪源胶原基质(CM)和游离牙龈移植物(FGG)在 24 个月的随访期内增加种植体角化组织(KT)的三维变化。

材料和方法

本回顾性研究纳入了 25 名患者,共 41 个种植体角化组织宽度不足(即<2mm)的患者,他们接受了软组织增量术,使用 CM(11 名患者/15 个种植体)或 FGG(14 名患者/26 个种植体)。主要结局是治疗后种植体部位组织厚度的变化(mm),包括 1 个月(S0)、12 个月(S1)和 24 个月(S2)。次要结局是 24 个月随访期间 KT 宽度的变化。

结果

从 S0 到 S1 和从 S0 到 S2 的三维分析显示,CM 组的组织厚度平均减少了-0.05±0.35mm 和-0.31±0.41mm,FGG 组分别减少了-0.23±0.38mm 和-0.22±0.81mm,两组之间无显著差异(S0-S1:p=0.14,S0-S2:p=0.58)。在 S1 和 S2 时,CM 和 FGG 组的组织厚度减少相当(CM:-0.32±0.53mm,FGG:-0.02±0.21mm;p=0.07)。与 CM 组相比,FGG 组在 24 个月时的 KT 获得明显更大(CM:1.50±1.14mm,FGG:4.04±1.65mm;p<0.001)。

结论

CM 和 FGG 在 24 个月的时间内与相似的三维厚度变化相关。FGG 组可建立更宽的 KT 带。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/60f91cbfc109/40729_2024_575_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/cfcede004bc4/40729_2024_575_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/aad259b1fdff/40729_2024_575_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/3d233acf2c2a/40729_2024_575_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/3a453d739d20/40729_2024_575_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/445d8c5776be/40729_2024_575_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/60f91cbfc109/40729_2024_575_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/cfcede004bc4/40729_2024_575_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/aad259b1fdff/40729_2024_575_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/3d233acf2c2a/40729_2024_575_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/3a453d739d20/40729_2024_575_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/445d8c5776be/40729_2024_575_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11557777/60f91cbfc109/40729_2024_575_Fig5_HTML.jpg

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本文引用的文献

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Three-dimensional changes of a porcine collagen matrix and free gingival grafts for soft tissue augmentation to increase the width of keratinized tissue around dental implants: a randomized controlled clinical study.三维猪胶原基质和游离龈瓣移植软组织增量以增加种植体周围角化组织宽度的研究:一项随机对照临床研究。
Int J Implant Dent. 2023 Jun 16;9(1):13. doi: 10.1186/s40729-023-00482-2.
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Relevant domains, core outcome sets and measurements for implant dentistry clinical trials: The Implant Dentistry Core Outcome Set and Measurement (ID-COSM) international consensus report.
种植义齿临床试验的相关领域、核心结局指标和测量:种植义齿核心结局指标和测量(ID-COSM)国际共识报告。
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Xenogeneic collagen matrix versus free gingival graft for augmenting keratinized mucosa around posterior mandibular implants: a randomized clinical trial.异种胶原基质与游离龈瓣移植在增加下颌后牙区种植体周围角化黏膜中的随机临床试验
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Clin Oral Implants Res. 2022 Jun;33 Suppl 23(Suppl 23):56-71. doi: 10.1111/clr.13789.
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Importance of keratinized mucosa around dental implants: Consensus report of group 1 of the DGI/SEPA/Osteology Workshop.种植体周围角化黏膜的重要性:DGI/SEPA/骨科学术研讨会第 1 组的共识报告。
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Effect of peri-implant mucosal thickness on esthetic outcomes and the efficacy of soft tissue augmentation procedures: Consensus report of group 2 of the SEPA/DGI/OF workshop.种植体周围黏膜厚度对美观效果和软组织增量手术效果的影响:SEPA/DGI/OF 研讨会第 2 组的共识报告。
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Dimensional changes of keratinized mucosa after accordion versus conventional free gingival graft around dental implants: A randomized two-arm parallel clinical trial.种植体周围应用波纹状与传统游离龈瓣移植术对角化黏膜外形改变的随机对照研究。
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It is all about peri-implant tissue health.一切都关乎种植体周围组织的健康。
Periodontol 2000. 2022 Feb;88(1):9-12. doi: 10.1111/prd.12407.