Molecular Biology and Genomics Core Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC.
Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC.
JCO Oncol Pract. 2024 Nov;20(11):1441-1451. doi: 10.1200/OP.24.00191. Epub 2024 Nov 12.
Pharmacogenomic (PGx) testing is a growing area of personalized medicine with demonstrated clinical utility in improving patient outcomes in oncology. PGx testing of pharmacogenes affecting drug pharmacokinetics, pharmacodynamics, and response can help inform drug selection and dosing of several anticancer therapies and supportive care medications. Several PGx testing techniques exist including polymerase chain reaction (PCR), MassARRAY, microarray, and sequencing. This review article provides a clinician-friendly guide of these techniques. Understanding the advantages, limitations, ideal use, and potential clinical applications of each platform can help clinicians choose the appropriate PGx testing platform for specific use cases.
药物基因组学（PGx）检测是个性化医学的一个新兴领域，已证明在改善肿瘤患者的治疗效果方面具有临床应用价值。对影响药物药代动力学、药效学和反应的药物基因进行 PGx 检测有助于为多种抗癌治疗药物和支持性护理药物提供药物选择和剂量建议。目前存在多种 PGx 检测技术，包括聚合酶链反应（PCR）、MassARRAY、微阵列和测序。本文为临床医生提供了这些技术的使用指南。了解每种平台的优势、局限性、理想用途和潜在临床应用，可以帮助临床医生为特定的应用场景选择合适的 PGx 检测平台。
