Simbirtseva Kseniya Y, O'Toole Paul W
APC Microbiome Ireland, University College Cork, Cork, Ireland.
School of Microbiology, University College Cork, Cork, Ireland; email:
Annu Rev Med. 2025 Jan;76(1):115-127. doi: 10.1146/annurev-med-042423-042542. Epub 2025 Jan 16.
An altered gut microbiome is a feature of many multifactorial diseases, and microbiome effects on host metabolism, immune function, and possibly neurological function are implicated. Increased biological age is accompanied by a change in the gut microbiome. However, age-related health loss does not occur uniformly across all subjects but rather depends on differential loss of gut commensals and gain of pathobionts. In this article, we summarize the known and possible effects of the gut microbiome on the hallmarks of aging and describe the most plausible mechanisms. Understanding and targeting these factors could lead to prolonging health span by rationally maintaining the gut microbiome.
肠道微生物群的改变是许多多因素疾病的一个特征，并且微生物群对宿主代谢、免疫功能以及可能的神经功能的影响也被牵涉其中。生物学年龄的增加伴随着肠道微生物群的变化。然而，与年龄相关的健康损失并非在所有受试者中均匀发生，而是取决于肠道共生菌的差异性减少和致病共生菌的增加。在本文中，我们总结了肠道微生物群对衰老特征的已知和可能的影响，并描述了最合理的机制。了解并针对这些因素可能会通过合理维持肠道微生物群来延长健康寿命。
