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使用自动双选择操作性测定法对小鼠社会和非社会奖赏寻求进行定量评估的方案。

Protocol for the quantitative assessment of social and nonsocial reward-seeking in mice using an automated two choice operant assay.

作者信息

Isaac Jennifer, Balasubramanian Hymavathy, Karkare Sonia Corbett, Schappaugh Nicholas, Murugan Malavika

机构信息

Emory Neuroscience Graduate Program, Emory University, Atlanta, GA 30322, USA; Department of Biology, Emory University, Atlanta, GA 30322, USA.

Department of Biology, Emory University, Atlanta, GA 30322, USA.

出版信息

STAR Protoc. 2025 Apr 25;6(2):103788. doi: 10.1016/j.xpro.2025.103788.

DOI:10.1016/j.xpro.2025.103788
PMID:40286274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12056402/
Abstract

The complexity of social behaviors makes it difficult to study the neural mechanisms that underlie them. Here, we describe an automated, low-cost two choice operant assay to directly compare social and nonsocial reward-seeking in mice. We provide instructions for the assembly of the operant chamber and conducting behavioral experiments, which include a graphical user interface (GUI)-based acquisition system that can be readily combined with various experimental manipulations. This assay allows for the characterization of social and nonsocial behaviors and their associated neural mechanisms. For complete details on the use and execution of this protocol, please refer to Isaac et al..

摘要

社会行为的复杂性使得研究其背后的神经机制变得困难。在此，我们描述了一种自动化、低成本的二选一操作性检测方法，用于直接比较小鼠的社会和非社会奖赏寻求行为。我们提供了操作性实验箱的组装说明以及进行行为实验的指导，其中包括一个基于图形用户界面（GUI）的采集系统，该系统可轻松与各种实验操作相结合。这种检测方法能够对社会和非社会行为及其相关神经机制进行表征。有关本方案使用和执行的完整详细信息，请参考艾萨克等人的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/b7e01e621b31/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/e9093885cb29/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/5a58c1cb985b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/2aa9b6794d1e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/d7d333439907/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/0350829ce340/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/b7e01e621b31/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/e9093885cb29/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/5a58c1cb985b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/2aa9b6794d1e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/d7d333439907/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/0350829ce340/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c660/12056402/b7e01e621b31/gr5.jpg

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本文引用的文献

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