用于酒精消费及酒精使用障碍诊断、预后和治疗的新一代生物标志物：一项批判性综述
Next-generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review.
作者信息
Clark Shaunna L, Hartwell Emily E, Choi Doo-Sup, Krystal John H, Messing Robert O, Ferguson Laura B
机构信息
Department of Psychiatry and Behavioral Sciences, Texas A&M University, College Station, Texas, USA.
Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.
出版信息
Alcohol Clin Exp Res (Hoboken). 2025 Jan;49(1):5-24. doi: 10.1111/acer.15476. Epub 2024 Nov 12.
This critical review summarizes the current state of omics-based biomarkers in the alcohol research field. We first provide definitions and background information on alcohol and alcohol use disorder (AUD), biomarkers, and "omic" technologies. We next summarize using (1) genetic information as risk/prognostic biomarkers for the onset of alcohol-related problems and the progression from regular drinking to problematic drinking (including AUD), (2) epigenetic information as diagnostic biomarkers for AUD and risk biomarkers for alcohol consumption, (3) transcriptomic information as diagnostic biomarkers for AUD, risk biomarkers for alcohol consumption, and (4) metabolomic information as diagnostic biomarkers for AUD, risk biomarkers for alcohol consumption, and predictive biomarkers for response to acamprosate in subjects with AUD. In the final section, the clinical implications of the findings are discussed, and recommendations are made for future research.
这篇批判性综述总结了酒精研究领域中基于组学的生物标志物的现状。我们首先提供关于酒精和酒精使用障碍（AUD）、生物标志物以及“组学”技术的定义和背景信息。接下来，我们总结了以下内容：（1）将遗传信息用作酒精相关问题发生以及从规律饮酒发展到问题饮酒（包括酒精使用障碍）的风险/预后生物标志物；（2）将表观遗传信息用作酒精使用障碍的诊断生物标志物以及酒精消费的风险生物标志物；（3）将转录组信息用作酒精使用障碍的诊断生物标志物、酒精消费的风险生物标志物；（4）将代谢组信息用作酒精使用障碍的诊断生物标志物、酒精消费的风险生物标志物以及酒精使用障碍患者对阿坎酸反应的预测生物标志物。在最后一部分，讨论了研究结果的临床意义，并对未来研究提出了建议。
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