Ericsson A, Granström M, Möllby R, Strandvik B
Acta Paediatr Scand. 1986 Jan;75(1):139-44. doi: 10.1111/j.1651-2227.1986.tb10170.x.
Enzyme-linked immunosorbent assay (ELISA) was used for IgG antibody determination to teichoic acid and alpha-toxin from Staphylococcus aureus in 65 patients with cystic fibrosis (CF). In patients chronically colonized with S. aureus, elevated titres to teichoic acid were found in 13/35 (37%) patients, to alpha-toxin in 12/35 (34%) and to either antigen in 18/35 (51%). Patients with elevated titres to teichoic acid had a significantly lower X-ray score than patients with normal titres. The highest titres against both teichoic acid and alpha-toxin were seen in patients not receiving optimal treatment. These findings suggest that staphylococci contribute to the tissue damage in CF and that the determination of antibodies especially to staphylococcal teichoic acid might be of value in the diagnosis and management of staphylococcal infections in patients with CF.
采用酶联免疫吸附测定法（ELISA）对65例囊性纤维化（CF）患者进行了针对金黄色葡萄球菌磷壁酸和α毒素的IgG抗体检测。在长期被金黄色葡萄球菌定植的患者中，13/35（37%）的患者磷壁酸滴度升高，12/35（34%）的患者α毒素滴度升高，18/35（51%）的患者两种抗原中任一种滴度升高。磷壁酸滴度升高的患者X线评分显著低于滴度正常的患者。未接受最佳治疗的患者针对磷壁酸和α毒素的滴度最高。这些发现表明葡萄球菌会导致CF患者的组织损伤，并且检测尤其是针对葡萄球菌磷壁酸的抗体可能对CF患者葡萄球菌感染的诊断和管理具有价值。
