School of Basic Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310053, China.
Sci Rep. 2024 Nov 12;14(1):27735. doi: 10.1038/s41598-024-78345-y.
Depression impairs self-management in diabetic patients, exacerbates insulin resistance, and elevates glycated hemoglobin (HbA1c) levels, thereby increasing diabetes risk. This study analyzed data from 30,386 participants in the National Health and Nutrition Examination Survey (NHANES), assessing depression severity using the 9-item Patient Health Questionnaire (PHQ-9) and evaluating diabetes status through clinical markers such as HbA1c, random blood glucose, and fasting blood glucose. Participants were stratified by depression severity and diabetes status to examine the relationship between depression and diabetes risk. We applied descriptive statistics, logistic regression models, subgroup analyses, and restricted cubic spline (RCS) modeling to explore this association. The results revealed that greater depression severity was significantly associated with increased diabetes incidence, elevated HbA1c, fasting glucose, and insulin levels. Multivariate regression analysis confirmed a consistent positive correlation between depression severity and diabetes risk. Subgroup analyses further identified significant relationships between depression and various demographic and behavioral factors, including gender, race, BMI, smoking status, and prediabetic conditions. Additionally, the RCS model demonstrated a clear increase in diabetes risk with rising PHQ-9 scores. In conclusion, our study demonstrates that the severity of depression is positively correlated with the risk of diabetes, and this association may be closely linked to various glycemic and lipid metabolic parameters.
抑郁会损害糖尿病患者的自我管理能力，加重胰岛素抵抗，升高糖化血红蛋白（HbA1c）水平，从而增加糖尿病风险。本研究分析了来自 30386 名国家健康和营养检查调查（NHANES）参与者的数据，使用 9 项患者健康问卷（PHQ-9）评估抑郁严重程度，并通过 HbA1c、随机血糖和空腹血糖等临床标志物评估糖尿病状况。根据抑郁严重程度和糖尿病状况对参与者进行分层，以检查抑郁与糖尿病风险之间的关系。我们应用描述性统计、逻辑回归模型、亚组分析和限制性立方样条（RCS）模型来探讨这种关联。结果表明，抑郁严重程度越高，糖尿病发病率越高，HbA1c、空腹血糖和胰岛素水平也越高。多变量回归分析证实了抑郁严重程度与糖尿病风险之间的一致性正相关。亚组分析进一步确定了抑郁与包括性别、种族、BMI、吸烟状况和糖尿病前期状况在内的各种人口统计学和行为因素之间的显著关系。此外，RCS 模型表明，随着 PHQ-9 评分的升高，糖尿病风险明显增加。总之，我们的研究表明，抑郁的严重程度与糖尿病的风险呈正相关，这种关联可能与各种血糖和脂质代谢参数密切相关。
